Per1 - period circadian clock 1 Gene

Also Known as Per; Hftm; mPer1; m-rigui

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18626

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]

Per1 Products (2)

mRNA Protein Name
NM_001159367.2 NP_001152839.1 period circadian protein homolog 1
NM_011065.5 NP_035195.2 period circadian protein homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
24154698 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
24610784 MGI
enables kinase binding IPI
IPI: Inferred from physical interaction
14701732 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9856465 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
24413057 MGI
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
21680841 MGI
involved in circadian regulation of gene expression IDA
IDA: Inferred from direct assay
20159955 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
15888647 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
14645221 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: Inferred from mutant phenotype
15888647 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9856465 MGI
involved in negative regulation of glucocorticoid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24378737 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9989497 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12397359 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24610784 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24610784 MGI
involved in post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
15888647 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
11395012 MGI
involved in regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
24610784 MGI
involved in response to cAMP IDA
IDA: Inferred from direct assay
23443664 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11591712 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

period circadian protein homolog 1

  • circadian clock protein PERIOD 1

  • circadian pacemaker protein Rigui

  • period homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125145 AA92593 Antagonist 99.94% Unkown
HY-N10987 Spiranthesol / Unkown
HY-N18371 Decumbenine / Unkown
HY-RS10331 PER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19930 Per1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26432 Per1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Per1 NCBI NCBI:5187