Prf1 - perforin 1 (pore forming protein) Gene

Also Known as Pfn; Pfp; Prf-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18646

Summary

Enables calcium ion binding activity and wide pore channel activity. Involved in several processes, including defense response to tumor cell; immune response to tumor cell; and protein homooligomerization. Acts upstream of or within T cell mediated cytotoxicity. Located in cytolytic granule and cytoplasmic vesicle. Is integral component of membrane. Is expressed in ductus deferens; epididymis; skin; and spleen. Used to study familial hemophagocytic lymphohistiocytosis 2; multiple sclerosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1). [provided by Alliance of Genome Resources, Apr 2022]

Prf1 Products (1)

mRNA	Protein	Name
NM_011073.3	NP_035203.3	perforin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	21037563	MGI
enables wide pore channel activity	IDA IDA: Inferred from direct assay	21037563	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	15454490	MGI
involved in T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	21037563	MGI
involved in T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	7972104	MGI
involved in defense response to tumor cell	IMP IMP: Inferred from mutant phenotype	8164737	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	8164737	MGI
involved in granzyme-mediated programmed cell death signaling pathway	IDA IDA: Inferred from direct assay	35705808	MGI
involved in immune response to tumor cell	IMP IMP: Inferred from mutant phenotype	8164737	MGI
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	21037563	MGI
involved in protein import	IDA IDA: Inferred from direct assay	21037563	MGI
involved in protein secretion	IDA IDA: Inferred from direct assay	35705808	MGI
involved in protein transmembrane transport	IDA IDA: Inferred from direct assay	21037563	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytolytic granule	IDA IDA: Inferred from direct assay	8164737	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	11856751	MGI
is active in immunological synapse	IDA IDA: Inferred from direct assay	8164737	MGI
is active in membrane	IDA IDA: Inferred from direct assay	21037563	MGI
located in membrane	IDA IDA: Inferred from direct assay	21037563	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	35705808	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
perforin-1	P1 cytolysin lymphocyte pore-forming protein pore forming protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19938	Prf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11087	PRF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16136	ZNF395 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26440	Prf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prf1	NCBI	NCBI:5551