Prkcg - protein kinase C, gamma Gene

Also Known as Pkcc; Prkcc; PKCgamma

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18752

About Prkcg

Chromosome 7: 3,337,704-3,379,615 forward strand.GRCm39:CM001000.3

This gene has 5 transcripts (splice variants), 201 orthologues, 9 paralogues and is associated with 13 phenotypes. Biased expression in cerebellum adult (RPKM 34.3), frontal lobe adult (RPKM 31.8) and 5 other tissues.

Summary

Predicted to enable calcium-dependent protein kinase C activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cellular protein metabolic process; and response to morphine. Acts upstream of or within chemosensory behavior and regulation of phagocytosis. Located in several cellular components, including calyx of Held; postsynaptic density; and synaptic membrane. Is active in presynaptic cytosol. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Apr 2022]

Prkcg Products (2)

mRNA Protein Name
NM_001291434.1 NP_001278363.1 protein kinase C gamma type isoform 2
NM_011102.4 NP_035232.1 protein kinase C gamma type isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: Inferred from direct assay
23115168 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23185022 MGI
Biological Process GO Annotation Evidence References Source
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
8548809 MGI
acts upstream of or within chemosensory behavior IMP
IMP: Inferred from mutant phenotype
11606660 MGI
involved in innervation IMP
IMP: Inferred from mutant phenotype
8548809 MGI
involved in negative regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
23185022 MGI
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
23185022 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
23115168 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
24794094 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
24794094 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
23185022 MGI
acts upstream of or within regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
15006698 MGI
involved in regulation of response to food IMP
IMP: Inferred from mutant phenotype
23185022 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
24794094 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
24794094 MGI
involved in response to morphine IMP
IMP: Inferred from mutant phenotype
11246146 MGI
involved in response to pain IMP
IMP: Inferred from mutant phenotype
9323205 MGI
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
24794094 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
24794094 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10882525 MGI
located in dendrite IDA
IDA: Inferred from direct assay
11549583 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10882525 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10882525 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
24794094 MGI
located in synaptic membrane IDA
IDA: Inferred from direct assay
18473171 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcg Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (33 - 90)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (100 - 153)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (157 - 288)

STKc_cPKC

STKc_cPKC: cd05587 (353 - 676)

  • 0
  • 200
  • 400
  • 600
  • 697 a.a.
Protein Preferred Names Protein Names

protein kinase C gamma type

  • PKC-gamma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11128 PRKCG Human Pre-designed siRNA Set A / Unkown
HY-RS11129 Prkcg Mouse Pre-designed siRNA Set A / Unkown
HY-RS11130 Prkcg Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkcg NCBI NCBI:5582