Prkcz - protein kinase C, zeta Gene

Also Known as Pkcz; zetaPKC; aPKCzeta; nPKC-zeta

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18762

About Prkcz

Chromosome 4: 155,344,586-155,445,818 reverse strand.GRCm39:CM000997.3

This gene has 10 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 22 phenotypes. Broad expression in cortex adult (RPKM 34.2), cerebellum adult (RPKM 31.5) and 19 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in positive regulation of T-helper 2 cell differentiation and positive regulation of cytokine production. Acts upstream of or within several processes, including neuron projection extension; protein localization to plasma membrane; and protein phosphorylation. Located in several cellular components, including axon hillock; myelin sheath abaxonal region; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcz Products (3)

mRNA	Protein	Name
NM_001355178.1	NP_001342107.1	protein kinase C zeta type isoform c
NM_008860.3	NP_032886.2	protein kinase C zeta type isoform a
NM_001039079.2	NP_001034168.1	protein kinase C zeta type isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16792529	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	14730360	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21131967	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	19668197	MGI
acts upstream of or within microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15882626	MGI
acts upstream of or within neuron projection extension	IGI IGI: Inferred from genetic interaction	19668197	MGI
involved in positive regulation of T-helper 2 cell cytokine production	IMP IMP: Inferred from mutant phenotype	15987782	MGI
involved in positive regulation of T-helper 2 cell differentiation	IMP IMP: Inferred from mutant phenotype	15987782	MGI
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	15987782	MGI
involved in positive regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	15987782	MGI
involved in positive regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	15987782	MGI
involved in positive regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	15987782	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	16455755	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	14730360	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical cortex	IDA IDA: Inferred from direct assay	15950600	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20551175	MGI
located in axon hillock	IDA IDA: Inferred from direct assay	19668197	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	15775979	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	15950600	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10882525	MGI
located in microtubule organizing center	IGI IGI: Inferred from genetic interaction	19668197	MGI
located in myelin sheath abaxonal region	IDA IDA: Inferred from direct assay	20237282	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	10882525	MGI
located in nuclear matrix	IDA IDA: Inferred from direct assay	10882525	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10882525	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10882525	MGI
located in vesicle	IDA IDA: Inferred from direct assay	17313651	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcz Protein Structure

PB1_aPKC

C1

PKc_like

0
100
200
300
400
500
592 a.a.

Protein Preferred Names	Protein Names
protein kinase C zeta type	atypical protein kinase C protein kinase C zeta subspecies

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11141	PRKCZ Human Pre-designed siRNA Set A		/	Unkown
HY-RS11142	Prkcz Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11143	Prkcz Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcz	NCBI	NCBI:5590