Plcg1 - phospholipase C, gamma 1 Gene

Also Known as Cded; Plc-1; Plcg-1; Plc-gamma1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18803

Summary

Enables glutamate receptor binding activity; phosphatidylinositol Phospholipase C activity; and receptor tyrosine kinase binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within T cell receptor signaling pathway and in utero embryonic development. Located in Schaffer collateral - CA1 synapse; cell-cell junction; and glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Orthologous to human PLCG1 (Phospholipase C gamma 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcg1 Products (1)

mRNA Protein Name
NM_021280.3 NP_067255.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutamate receptor binding IPI
IPI: Inferred from physical interaction
16710293 MGI
enables phosphatidylinositol phospholipase C activity EXP
EXP: Inferred from Experiment
8615781 MGI
enables phospholipase C activity IMP
IMP: Inferred from mutant phenotype
28004780 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12937273 MGI
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
12367511 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
15728238 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
11744703 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
28138157 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
28138157 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
28138157 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
28138157 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28138157 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28138157 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

  • PLC-gamma-1

  • cell differentiation and embryonic development

  • phosphoinositide phospholipase C-gamma-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10660 PLCG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19470 Plcg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25963 Plcg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plcg1 NCBI NCBI:5335