Pon1 - paraoxonase 1 Gene

Also Known as Pon

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18979

Summary

Enables arylesterase activity. Acts upstream of or within Cholesterol metabolic process and response to toxic substance. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic Cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pon1 Products (4)

mRNA Protein Name
NM_001410259.1 NP_001397188.1 serum paraoxonase/arylesterase 1 isoform 2 precursor
NM_001410260.1 NP_001397189.1 serum paraoxonase/arylesterase 1 isoform 3 precursor
NM_001410261.1 NP_001397190.1 serum paraoxonase/arylesterase 1 isoform 4 precursor
NM_011134.4 NP_035264.2 serum paraoxonase/arylesterase 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables arylesterase activity IMP
IMP: Inferred from mutant phenotype
9685159 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
9685159 MGI
acts upstream of or within response to toxic substance IMP
IMP: Inferred from mutant phenotype
9685159 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serum paraoxonase/arylesterase 1

  • A-esterase 1

  • PON 1

  • aromatic esterase 1

  • serum aryldialkylphosphatase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143239 PPARα/γ agonist 1 Agonist 99.69% Unkown
HY-W015892 γ-Hexalactone 99.77% Unkown
HY-B0815S Chlorpyrifos-d10 Inhibitor 99.49% Unkown
HY-W017445 Homogentisic acid lactone Inhibitor 99.11% Unkown
HY-130220 (±)5-HETE lactone / Unkown
HY-146058 NF-κB/PON1-IN-1 Inhibitor / Unkown
HY-RS10872 PON1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17965 Pon1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24436 Pon1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W015892R γ-Hexalactone (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pon1 NCBI NCBI:5444