2. Gene
  3. Ppard - peroxisome proliferator activator receptor delta Gene

Ppard - peroxisome proliferator activator receptor delta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta

Gene ID: 19015 | Gene type: protein coding

About Ppard

Chromosome 17: 28,451,674-28,520,448 forward strand.GRCm39:CM001010.3

This gene has 9 transcripts (splice variants), 421 orthologues, 19 paralogues and is associated with 77 phenotypes. Broad expression in duodenum adult (RPKM 12.2), colon adult (RPKM 88.9) and 16 other tissues.

Summary

Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts upstream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase signaling. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Ppard Products(7)

mRNA Protein Name
NM_001411522.1 NP_001398451.1 peroxisome proliferator-activated receptor delta isoform 5
NM_001411526.1 NP_001398455.1 peroxisome proliferator-activated receptor delta isoform 1
NM_001411510.1 NP_001398439.1 peroxisome proliferator-activated receptor delta isoform 1
NM_001411509.1 NP_001398438.1 peroxisome proliferator-activated receptor delta isoform 2
NM_011145.4 NP_035275.1 peroxisome proliferator-activated receptor delta isoform 1
NM_001411521.1 NP_001398450.1 peroxisome proliferator-activated receptor delta isoform 4
NM_001411520.1 NP_001398449.1 peroxisome proliferator-activated receptor delta isoform 3

Ppard Protein Structure

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (71 - 154)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (171 - 438)

  • 0
  • 100
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  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor delta

PPARdelta/beta

Peroxisome proliferator-activated receptor beta

nuclear hormone receptor 1

nuclear receptor subfamily 1 group C member 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10922 PPARD Human Pre-designed siRNA Set A / Unkown
HY-RS10923 Ppard Mouse Pre-designed siRNA Set A / Unkown
HY-RS10924 Ppard Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppard NCBI NCBI:5467