Ppard - peroxisome proliferator activator receptor delta Gene

Also Known as NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19015

About Ppard

Chromosome 17: 28,451,674-28,520,448 forward strand.GRCm39:CM001010.3

This gene has 9 transcripts (splice variants), 421 orthologues, 19 paralogues and is associated with 77 phenotypes. Broad expression in duodenum adult (RPKM 12.2), colon adult (RPKM 88.9) and 16 other tissues.

Summary

Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts upstream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase signaling. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Ppard Products (7)

mRNA Protein Name
NM_001411522.1 NP_001398451.1 peroxisome proliferator-activated receptor delta isoform 5
NM_001411526.1 NP_001398455.1 peroxisome proliferator-activated receptor delta isoform 1
NM_001411510.1 NP_001398439.1 peroxisome proliferator-activated receptor delta isoform 1
NM_001411509.1 NP_001398438.1 peroxisome proliferator-activated receptor delta isoform 2
NM_011145.4 NP_035275.1 peroxisome proliferator-activated receptor delta isoform 1
NM_001411521.1 NP_001398450.1 peroxisome proliferator-activated receptor delta isoform 4
NM_001411520.1 NP_001398449.1 peroxisome proliferator-activated receptor delta isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
8041794 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20445066 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10385625 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adipose tissue development IMP
IMP: Inferred from mutant phenotype
11756685 MGI
acts upstream of or within anagen IMP
IMP: Inferred from mutant phenotype
15713628 MGI
acts upstream of or within axon ensheathment IMP
IMP: Inferred from mutant phenotype
10866668 MGI
acts upstream of or within cell differentiation IDA
IDA: Inferred from direct assay
16581799 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
16581799 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11756685 MGI
acts upstream of or within cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
11514592 MGI
acts upstream of or within cellular response to hypoxia IGI
IGI: Inferred from genetic interaction
24011070 MGI
acts upstream of or within embryo implantation IDA
IDA: Inferred from direct assay
10385625 MGI
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
19345188 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
11756685 MGI
acts upstream of fat cell proliferation IMP
IMP: Inferred from mutant phenotype
11756685 MGI
involved in fatty acid beta-oxidation IEP
IEP: Inferred from expression pattern
14676330 MGI
involved in fatty acid transport IEP
IEP: Inferred from expression pattern
14676330 MGI
acts upstream of or within keratinocyte migration IMP
IMP: Inferred from mutant phenotype
11514592 MGI
acts upstream of or within keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
11511099 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
10866668 MGI
NOT acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
11756685 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
14758356 MGI
involved in negative regulation of miRNA transcription IDA
IDA: Inferred from direct assay
20445066 MGI
involved in negative regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
22040534 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8041794 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
16581799 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
11756685 MGI
acts upstream of or within positive regulation of fat cell proliferation IMP
IMP: Inferred from mutant phenotype
11756685 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22040534 MGI
involved in positive regulation of myoblast proliferation IMP
IMP: Inferred from mutant phenotype
22040534 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
16581799 MGI
involved in positive regulation of skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
22040534 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15380519 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10866668 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
11756685 MGI
involved in regulation of skeletal muscle satellite cell proliferation IMP
IMP: Inferred from mutant phenotype
22040534 MGI
acts upstream of or within wound healing IMP
IMP: Inferred from mutant phenotype
11514592 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
20445066 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10385625 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ppard Protein Structure

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (71 - 154)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (171 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor delta

  • PPARdelta/beta

  • Peroxisome proliferator-activated receptor beta

  • nuclear hormone receptor 1

  • nuclear receptor subfamily 1 group C member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10922 PPARD Human Pre-designed siRNA Set A / Unkown
HY-RS10923 Ppard Mouse Pre-designed siRNA Set A / Unkown
HY-121579 L-764406 Agonist / Unkown
HY-RS10924 Ppard Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppard NCBI NCBI:5467