Prkar2a - protein kinase, cAMP dependent regulatory, type II alpha Gene

Also Known as RII(alpha); 1110061A24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19087

Summary

Predicted to enable several functions, including beta-2 Adrenergic Receptor binding activity; cAMP binding activity; and enzyme binding activity. Involved in modulation of chemical synaptic transmission. Located in cytoplasm and glutamatergic synapse. Part of cAMP-dependent protein kinase complex. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkar2a Products (1)

mRNA Protein Name
NM_008924.3 NP_032950.1 cAMP-dependent protein kinase type II-alpha regulatory subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9852104 MGI
Biological Process GO Annotation Evidence References Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
15255994 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
15255994 MGI
Cellular Component GO Annotation Evidence References Source
part of cAMP-dependent protein kinase complex IDA
IDA: Inferred from direct assay
21502359 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21502359 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
24413018 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15255994 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15255994 MGI
is active in synapse EXP
EXP: Inferred from Experiment
24413018 MGI
is active in synapse IDA
IDA: Inferred from direct assay
24413018 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-dependent protein kinase type II-alpha regulatory subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11114 PRKAR2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22020 Prkar2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28538 Prkar2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkar2a NCBI NCBI:5576