Prkg1 - protein kinase, cGMP-dependent, type I Gene

Also Known as CGKI; Prkg1b; Gm19690; Prkgr1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19091

Summary

Enables cGMP binding activity and cGMP-dependent protein kinase activity. Involved in protein phosphorylation and signal transduction. Acts upstream of or within cGMP-mediated signaling; nervous system development; and relaxation of vascular associated smooth muscle. Located in Golgi apparatus and plasma membrane. Is expressed in several structures, including bone; central nervous system; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Apr 2022]

Prkg1 Products (3)

mRNA Protein Name
NM_001013833.3 NP_001013855.1 cGMP-dependent protein kinase 1 isoform alpha
NM_001411181.1 NP_001398110.1 cGMP-dependent protein kinase 1 isoform alpha
NM_011160.3 NP_035290.1 cGMP-dependent protein kinase 1 isoform beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cGMP binding IDA
IDA: Inferred from direct assay
10671526 MGI
enables cGMP-dependent protein kinase activity IDA
IDA: Inferred from direct assay
10671526 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10671526 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
10671526 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cGMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
15483626 MGI
involved in collateral sprouting IMP
IMP: Inferred from mutant phenotype
17954614 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
16154207 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
16154207 MGI
acts upstream of or within negative regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
15483626 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
16154207 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10671526 MGI
acts upstream of or within relaxation of vascular associated smooth muscle IMP
IMP: Inferred from mutant phenotype
15483626 MGI
involved in signal transduction IDA
IDA: Inferred from direct assay
10671526 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10671526 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16990611 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
19127022 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cGMP-dependent protein kinase 1

  • cGK 1

  • cGK1

  • cGMP-dependent protein kinase I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11154 PRKG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20087 Prkg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26590 Prkg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkg1 NCBI NCBI:5592