Pstpip1 - proline-serine-threonine phosphatase-interacting protein 1 Gene
Also Known as def-2; CD2BP1
Species: Mus musculus
Summary
Enables actin binding activity and protein Phosphatase binding activity. Predicted to be involved in actin filament polymerization. Predicted to act upstream of or within several processes, including endocytosis; inflammatory response; and innate immune response. Located in actomyosin contractile ring; cleavage furrow; and stress fiber. Is expressed in several structures, including genitourinary system; lung; musculature; pancreas; and spleen. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine Phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Pstpip1 Products (13)
| mRNA | Protein | Name |
|---|---|---|
| NM_001409150.1 | NP_001396079.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 2 |
| NM_001409151.1 | NP_001396080.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 3 |
| NM_001409152.1 | NP_001396081.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 4 |
| NM_001409153.1 | NP_001396082.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 5 |
| NM_001409154.1 | NP_001396083.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 6 |
| NM_001409155.1 | NP_001396084.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 7 |
| NM_001409156.1 | NP_001396085.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 8 |
| NM_001409157.1 | NP_001396086.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 9 |
| NM_001409158.1 | NP_001396087.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 10 |
| NM_001409159.1 | NP_001396088.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 11 |
| NM_001409160.1 | NP_001396089.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 11 |
| NM_001409161.1 | NP_001396090.1 | proline-serine-threonine phosphatase-interacting protein 1 isoform 11 |
| NM_011193.3 | NP_035323.2 | proline-serine-threonine phosphatase-interacting protein 1 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables actin binding |
IDA
IDA: Inferred from direct assay
|
9265651 | MGI |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9265651 | MGI |
| enables protein phosphatase binding |
IDA
IDA: Inferred from direct assay
|
9265651 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in actomyosin contractile ring |
IDA
IDA: Inferred from direct assay
|
9265651 | MGI |
| located in cleavage furrow |
IDA
IDA: Inferred from direct assay
|
9265651 | MGI |
| located in stress fiber |
IDA
IDA: Inferred from direct assay
|
9265651 | MGI |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
proline-serine-threonine phosphatase-interacting protein 1 |
|
Pstpip1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
Pstpip1 | P97814 | Ptpn12 | Mus musculus | P35831 | 16204241 | |
|
Intra
|
Pstpip1 | P97814 | Ptpn12 | Mus musculus | P35831 | 11711533 | |
|
Intra
|
Pstpip1 | P97814 | Ptpn12 | Mus musculus | P35831 | 11711533 | |
|
Intra
|
Pstpip1 | P97814 | Ptpn18 | Mus musculus | Q61152 | 9804817 | |
|
Intra
|
Pstpip1 | P97814 | Abl1 | Mus musculus | P00520 | 11163214 | |
|
Intra
|
Pstpip1 | P97814 | Abl1 | Mus musculus | P00520 | 11163214 |
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS11345 | PSTPIP1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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