Ptgdr - prostaglandin D receptor Gene

Also Known as DP; PGD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19214

About Ptgdr

Chromosome 14: 45,088,692-45,096,832 reverse strand.GRCm39:CM001007.3

This gene has 1 transcript (splice variant), 117 orthologues, 7 paralogues and is associated with 18 phenotypes. Biased expression in testis adult (RPKM 1.2), CNS E18 (RPKM .5) and 14 other tissues.

Summary

Enables prostaglandin D receptor activity and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenosine metabolic process; cellular response to prostaglandin D stimulus; and male sex determination. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR (prostaglandin D2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ptgdr Products (1)

mRNA Protein Name
NM_008962.4 NP_032988.3 prostaglandin D2 receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables prostaglandin D receptor activity IDA
IDA: Inferred from direct assay
12878180 MGI
enables prostaglandin J receptor activity IDA
IDA: Inferred from direct assay
12878180 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenosine metabolic process IMP
IMP: Inferred from mutant phenotype
11562489 MGI
acts upstream of or within cellular response to prostaglandin D stimulus IMP
IMP: Inferred from mutant phenotype
11562489 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
15834430 MGI
acts upstream of or within male sex determination IMP
IMP: Inferred from mutant phenotype
16185683 MGI
acts upstream of or within sleep IMP
IMP: Inferred from mutant phenotype
11562489 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11562489 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptgdr Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (15 - 330)

7tm_GPCRs

7tm_GPCRs: cd14964 (17 - 41)

7tm_GPCRs

7tm_GPCRs: cd14964 (60 - 82)

7tm_GPCRs

7tm_GPCRs: cd14964 (104 - 126)

7tm_GPCRs

7tm_GPCRs: cd14964 (149 - 165)

7tm_GPCRs

7tm_GPCRs: cd14964 (194 - 217)

7tm_GPCRs

7tm_GPCRs: cd14964 (262 - 284)

7tm_GPCRs

7tm_GPCRs: cd14964 (297 - 322)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
Protein Preferred Names Protein Names

prostaglandin D2 receptor

  • PGD receptor

  • PGD2 receptor

  • prostanoid DP receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15950 AZD1981 Antagonist 99.80% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11368 PTGDR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11369 Ptgdr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11370 PTGDR Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11371 PTGDR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11372 Ptgdr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11373 Ptgdr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgdr NCBI NCBI:5729