PTGDR - prostaglandin D2 receptor Gene

Also Known as DP; AS1; DP1; ASRT1; PTGDR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5729

About PTGDR

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,267,698-52,280,914 (from NCBI)

This gene has 2 transcripts (splice variants), 117 orthologues, 7 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 1.6), colon (RPKM 1.3) and 19 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PTGDR Products (3)

mRNA Protein Name
NM_001281469.2 NP_001268398.1 prostaglandin D2 receptor isoform 2
NM_000953.3 NP_000944.1 prostaglandin D2 receptor isoform 1
XM_005267891.5 XP_005267948.1 prostaglandin D2 receptor isoform X1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20959461 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20959461 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGDR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 323)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

prostaglandin D2 receptor

  • PGD2 receptor

PTGDR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTGDR Q13258 GGA3 Homo sapiens Q9NZ52
Pull Down
32334026
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dermatitis

  • Eczema

  • Skin Inflammation

  • Inflammatory Dermatosis
Anemia Of Prematurity
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Retinitis Pigmentosa 11

  • RP11

  • Retinitis Pigmentosa-11

  • Retinitis Pigmentosa, Type 11
Spermatogenic Failure 24

  • SPGF24

  • Spermatogenic Failure, Type 24
Asthma-Related Traits 1

  • Asthma-Related Traits, Susceptibility To, 1

  • ASRT1

  • Asthma, Susceptibility To, 1

  • As1

  • Asthma 1

  • Asthma-Related Traits, Susceptibility To, Type 1
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15950 AZD1981 Antagonist 99.80% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11368 PTGDR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11369 Ptgdr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11370 PTGDR Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11371 PTGDR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11372 Ptgdr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11373 Ptgdr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PTGDR RGD RGD:619707
Bos taurus PTGDR VGNC VGNC:33499
Mus musculus PTGDR MGD MGI:102966
Macaca mulatta PTGDR VGNC VGNC:76467
Canis familiaris PTGDR VGNC VGNC:45140
Others PTGDR NCBI