PTGDR - prostaglandin D2 receptor Gene

Homo sapiens

Also known as DP; AS1; DP1; ASRT1; PTGDR1

Gene ID: 5729 | Gene type: protein coding

About PTGDR

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,267,698-52,280,914 (from NCBI)

This gene has 2 transcripts (splice variants), 117 orthologues, 7 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 1.6), colon (RPKM 1.3) and 19 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PTGDR Products(3)

mRNA	Protein	Name
NM_001281469.2	NP_001268398.1	prostaglandin D2 receptor isoform 2
NM_000953.3	NP_000944.1	prostaglandin D2 receptor isoform 1
XM_005267891.5	XP_005267948.1	prostaglandin D2 receptor isoform X1

PTGDR Protein Structure

7tm_1

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

prostaglandin D2 receptor

PGD2 receptor

Related Diseases

Diseases

Alias

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Anemia Of Prematurity

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Spermatogenic Failure 24

SPGF24

Spermatogenic Failure, Type 24

Asthma-Related Traits 1

Asthma-Related Traits, Susceptibility To, 1	ASRT1
Asthma, Susceptibility To, 1	As1
Asthma 1	Asthma-Related Traits, Susceptibility To, Type 1

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS11368	PTGDR Human Pre-designed siRNA Set A	/	Unkown
HY-RS11369	Ptgdr Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11370	PTGDR Rat Pre-designed siRNA Set A	/	Unkown
HY-RS11371	PTGDR2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS11372	Ptgdr2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11373	Ptgdr2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTGDR	RGD	RGD:619707
Bos taurus	PTGDR	VGNC	VGNC:33499
Mus musculus	PTGDR	MGD	MGI:102966
Macaca mulatta	PTGDR	VGNC	VGNC:76467
Canis familiaris	PTGDR	VGNC	VGNC:45140

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