Ptpra - protein tyrosine phosphatase, receptor type, A Gene

Also Known as Ptpa; Rptra; Ptpalpha; Rptpalpha; Rptralpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19262

Summary

Enables protein tyrosine Phosphatase activity. Involved in integrin-mediated signaling pathway; modulation of chemical synaptic transmission; and regulation of focal adhesion assembly. Acts upstream of or within Insulin Receptor signaling pathway and protein phosphorylation. Located in focal adhesion and membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of synaptic membrane. Is expressed in several structures, including adrenal gland; central nervous system; decidua; extraembryonic component; and future brain. Orthologous to human PTPRA (protein tyrosine Phosphatase receptor type A). [provided by Alliance of Genome Resources, Apr 2022]

Ptpra Products (3)

mRNA Protein Name
NM_001163688.1 NP_001157160.1 receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor
NM_001355161.1 NP_001342090.1 receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor
NM_008980.2 NP_033006.2 receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7518772 MGI
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
22801373 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14733908 MGI
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22801373 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
12912911 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12912911 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
14733908 MGI
involved in regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
22801373 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
12912911 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
12912911 MGI
located in focal adhesion IMP
IMP: Inferred from mutant phenotype
22801373 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
22801373 MGI
is active in synaptic membrane IDA
IDA: Inferred from direct assay
16899073 MGI
is active in synaptic membrane IEP
IEP: Inferred from expression pattern
16899073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase alpha

  • LCA-related phosphatase

  • PTPTY-28

  • R-PTP-alpha

  • protein-tyrosine phosphatase alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11432 PTPRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19478 Ptpra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25971 Ptpra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptpra NCBI NCBI:5786