PTPRA - protein tyrosine phosphatase receptor type A Gene

Also Known as LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5786

About PTPRA

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,864,184-3,038,669 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 49.1), thyroid (RPKM 27.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of Integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

PTPRA Products (27)

mRNA Protein Name
NM_001385302.1 NP_001372231.1 receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor
NM_001385303.1 NP_001372232.1 receptor-type tyrosine-protein phosphatase alpha isoform 3 precursor
NM_001385304.1 NP_001372233.1 receptor-type tyrosine-protein phosphatase alpha isoform 4 precursor
NM_001385305.1 NP_001372234.1 receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor
NM_001385306.1 NP_001372235.1 receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor
NM_001385307.1 NP_001372236.1 receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor
NM_001385308.1 NP_001372237.1 receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor
NM_001385310.1 NP_001372239.1 receptor-type tyrosine-protein phosphatase alpha isoform 5 precursor
NM_001385311.1 NP_001372240.1 receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor
NM_001385312.1 NP_001372241.1 receptor-type tyrosine-protein phosphatase alpha isoform 6 precursor
NM_001385313.1 NP_001372242.1 receptor-type tyrosine-protein phosphatase alpha isoform 7 precursor
NM_001385314.1 NP_001372243.1 receptor-type tyrosine-protein phosphatase alpha isoform 8 precursor
NM_001385315.1 NP_001372244.1 receptor-type tyrosine-protein phosphatase alpha isoform 9 precursor
NM_001385316.1 NP_001372245.1 receptor-type tyrosine-protein phosphatase alpha isoform 10
NM_001385317.1 NP_001372246.1 receptor-type tyrosine-protein phosphatase alpha isoform 11 precursor
NM_001385318.1 NP_001372247.1 receptor-type tyrosine-protein phosphatase alpha isoform 12 precursor
NM_001385319.1 NP_001372248.1 receptor-type tyrosine-protein phosphatase alpha isoform 13 precursor
NM_001385320.1 NP_001372249.1 receptor-type tyrosine-protein phosphatase alpha isoform 13 precursor
NM_001385321.1 NP_001372250.1 receptor-type tyrosine-protein phosphatase alpha isoform 14 precursor
NM_001388320.1 NP_001375249.1 receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor
NM_001388321.1 NP_001375250.1 receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor
NM_001388322.1 NP_001375251.1 receptor-type tyrosine-protein phosphatase alpha isoform 15
NM_001388323.1 NP_001375252.1 receptor-type tyrosine-protein phosphatase alpha isoform 15
NM_001388324.1 NP_001375253.1 receptor-type tyrosine-protein phosphatase alpha isoform 15
NM_002836.4 NP_002827.1 receptor-type tyrosine-protein phosphatase alpha isoform 1 precursor
NM_080840.3 NP_543030.1 receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor
NM_080841.3 NP_543031.1 receptor-type tyrosine-protein phosphatase alpha isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7518772 GOA
Cellular Component GO Annotation Evidence References Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRA Protein Structure

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (265 - 500)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (558 - 790)

  • 0
  • 200
  • 400
  • 600
  • 802 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase alpha

  • Leukocyte common antigen-related peptide (protein tyrosine phosphate)

PTPRA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPRA P18433 EGFR Homo sapiens P00533
Anti Tag CoIP
28065597
Intra
PTPRA P18433 GRB2 Homo sapiens P62993
Anti Tag CoIP
28514442
Intra
PTPRA P18433 GRB2 Homo sapiens P62993
Pull Down
28330616
Intra
PTPRA P18433 GRB2 Homo sapiens P62993
Anti Bait CoIP
11923305
Intra
PTPRA P18433 GRB2 Homo sapiens P62993
Ub Reconstruction
28065597
Intra
PTPRA P18433 GRB2 Homo sapiens P62993
Anti Tag CoIP
33961781
Cross
PTPRA P18433 Fyn Mus musculus P39688
Anti Bait CoIP
9535845
Cross
PTPRA P18433 Fyn Mus musculus P39688
Anti Tag CoIP
9535845
Intra
PTPRA P18433 SRC Homo sapiens P12931
Anti Bait CoIP
11923305
Intra
PTPRA P18433 SRC Homo sapiens P12931
Anti Tag CoIP
33961781
Cross
PTPRA P18433 SRC Gallus gallus P00523
Pull Down
10698938
Cross
PTPRA P18433 SRC Gallus gallus P00523
Phosphatase Assay
11923305
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPRA Proteins

Cat. No. Product Name Accession Purity
HY-P76555 PTP alpha/PTPRA Protein, Human (sf9, His-GST) P18433-2 (A174-K793) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Common Peroneal Nerve Lesion

  • Lesion Of Lateral Popliteal Nerve

  • Fibular Neuropathy
Rasopathy

  • Ras/Mitogen-Activated Protein Kinase Syndrome
Noonan Syndrome 1

  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11432 PTPRA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19478 Ptpra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25971 Ptpra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PTPRA VGNC VGNC:69168
Rattus norvegicus PTPRA RGD RGD:3450
Canis familiaris PTPRA VGNC VGNC:45182
Bos taurus PTPRA VGNC VGNC:33544
Macaca mulatta PTPRA VGNC VGNC:76610
Mus musculus PTPRA MGD MGI:97808
Others PTPRA NCBI