Purb - purine rich element binding protein B Gene

Also Known as Cager-2; D11Bwg0414e; 2310015K15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19291

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; SMAD binding activity; and nucleic acid binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in heart and hindlimb muscle. Orthologous to human PURB (purine rich element binding protein B). [provided by Alliance of Genome Resources, Apr 2022]

Purb Products (1)

mRNA Protein Name
NM_011221.3 NP_035351.1 transcriptional activator protein Pur-beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15282343 MGI
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
10318844 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15282343 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
27064749 MGI
enables RNA binding IDA
IDA: Inferred from direct assay
23723417 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15282343 MGI
enables SMAD binding IDA
IDA: Inferred from direct assay
15282343 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
15282343 MGI
enables mRNA binding IDA
IDA: Inferred from direct assay
12933792 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15282343 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
10318844 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15282343 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15282343 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
23723417 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
31918924 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15282343 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional activator protein Pur-beta

  • PurB beta

  • purine-rich single-stranded DNA-binding protein beta

  • vascular actin single-stranded DNA-binding factor 2 p44 component

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11465 PURB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21412 Purb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27931 Purb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Purb NCBI NCBI:5814