2. Gene
  3. Rara - retinoic acid receptor, alpha Gene

Rara - retinoic acid receptor, alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as RAR; Nr1b1; RARalpha1

Gene ID: 19401 | Gene type: protein coding

About Rara

Chromosome 11: 98,818,644-98,865,768 forward strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 331 orthologues, 19 paralogues and is associated with 32 phenotypes. Ubiquitous expression in lung adult (RPKM 17.4), stomach adult (RPKM 16.8) and 27 other tissues.

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in several processes, including Sertoli cell fate commitment; cellular response to lipopolysaccharide; and germ cell development. Acts upstream of or within several processes, including animal organ development; negative regulation of cartilage development; and regulation of cellular macromolecule biosynthetic process. Located in several cellular components, including dendrite; neuronal cell body; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Rara Products(5)

mRNA Protein Name
NM_001177302.1 NP_001170773.1 retinoic acid receptor alpha isoform 1
NM_001361954.1 NP_001348883.1 retinoic acid receptor alpha isoform 3
NM_001177303.1 NP_001170774.1 retinoic acid receptor alpha isoform 1
NM_001176528.1 NP_001169999.1 retinoic acid receptor alpha isoform 2
NM_009024.2 NP_033050.2 retinoic acid receptor alpha isoform 1

Rara Protein Structure

NR_DBD_RAR

NR_DBD_RAR: cd06964 (81 - 165)

NR_LBD_RAR

NR_LBD_RAR: cd06937 (185 - 415)

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  • 462 a.a.
Protein Preferred Names Protein Names

retinoic acid receptor alpha

RAR alpha 1

RAR-alpha

nuclear receptor subfamily 1 group B member 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101106 AR7 Antagonist 98.85% Unkown
HY-RS11669 RARA Human Pre-designed siRNA Set A / Unkown
HY-RS11670 Rara Mouse Pre-designed siRNA Set A / Unkown
HY-RS11671 Rara Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rara NCBI NCBI:5914