Tet3 - tet methylcytosine dioxygenase 3 Gene

Also Known as B430006D22Rik; D230004J03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 194388

Summary

Enables methylcytosine dioxygenase activity. Involved in DNA demethylation of male pronucleus. Acts upstream of or within DNA demethylation. Located in cytoplasm; female pronucleus; and male pronucleus. Is expressed in several structures, including central nervous system; early conceptus; future brain; and genitourinary system. Orthologous to human TET3 (tet methylcytosine dioxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]

Tet3 Products (2)

mRNA Protein Name
NM_001347313.1 NP_001334242.1 methylcytosine dioxygenase TET3 isoform 1
NM_183138.2 NP_898961.2 methylcytosine dioxygenase TET3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5-methylcytosine dioxygenase activity IDA
IDA: Inferred from direct assay
19372391 MGI
enables 5-methylcytosine dioxygenase activity IMP
IMP: Inferred from mutant phenotype
21407207 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23353889 MGI
Biological Process GO Annotation Evidence References Source
involved in epigenetic programing of male pronucleus IMP
IMP: Inferred from mutant phenotype
21407207 MGI
acts upstream of or within positive regulation of gene expression via chromosomal CpG island demethylation IDA
IDA: Inferred from direct assay
20639862 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21892189 MGI
located in female pronucleus IDA
IDA: Inferred from direct assay
21321204 MGI
located in male pronucleus IDA
IDA: Inferred from direct assay
21892189 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methylcytosine dioxygenase TET3

  • probable methylcytosine dioxygenase TET3

  • tet oncogene family member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-402410 TETi76 Inhibitor 97.49% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tet3 NCBI NCBI:200424