Rgs2 - regulator of G-protein signaling 2 Gene

Also Known as GOS8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19735

Summary

Enables Adenylate Cyclase Inhibitor activity. Involved in several processes, including negative regulation of signal transduction; regulation of muscle system process; and relaxation of cardiac muscle. Acts upstream of or within brown fat cell differentiation and spermatogenesis. Located in cytoplasmic side of plasma membrane and cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and immune system. Orthologous to human RGS2 (regulator of G protein signaling 2). [provided by Alliance of Genome Resources, Apr 2022]

Rgs2 Products (1)

mRNA Protein Name
NM_009061.4 NP_033087.2 regulator of G-protein signaling 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenylate cyclase inhibitor activity IMP
IMP: Inferred from mutant phenotype
21164481 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17464283 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
involved in negative regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19127022 MGI
involved in negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
19127022 MGI
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
19127022 MGI
involved in negative regulation of phospholipase activity IMP
IMP: Inferred from mutant phenotype
19127022 MGI
involved in positive regulation of cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
19127022 MGI
involved in regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21291891 MGI
involved in relaxation of cardiac muscle IMP
IMP: Inferred from mutant phenotype
19127022 MGI
involved in relaxation of vascular associated smooth muscle IMP
IMP: Inferred from mutant phenotype
14608379 MGI
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
14581517 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
21291891 MGI
located in cytosol IMP
IMP: Inferred from mutant phenotype
19127022 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
19127022 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of G-protein signaling 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169282 RGS2–Galpha-q PPI-IN-1 Agonist / Unkown
HY-N20711 Usenamine A / Unkown
HY-RS11916 RGS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18970 Rgs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25460 Rgs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgs2 NCBI NCBI:5997