Polr1a - polymerase (RNA) I polypeptide A Gene

Also Known as mRPA1; 194kDa; RPA194; Rpo1-4; 2900087K15Rik; 3010014K16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20019

Summary

Predicted to enable RNA polymerase I activity and chromatin binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in negative regulation of protein localization to nucleolus and rRNA transcription. Located in chromosome and nucleus. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Polr1a Products (1)

mRNA Protein Name
NM_009088.3 NP_033114.3 DNA-directed RNA polymerase I subunit RPA1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9236775 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase I complex IDA
IDA: Inferred from direct assay
9236775 MGI
located in chromosome IDA
IDA: Inferred from direct assay
30272023 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9236775 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-directed RNA polymerase I subunit RPA1

  • DNA-directed RNA polymerase I largest subunit

  • DNA-directed RNA polymerase I subunit A

  • RNA polymerase 1-4 (194 kDa subunit)

  • RNA polymerase I 194 kDa subunit

  • RNA polymerase I subunit A1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10837 POLR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21909 Polr1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Polr1a NCBI NCBI:25885