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KLHDC8B - kelch domain containing 8B Gene

Also Known as CHL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 200942

About KLHDC8B

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,171,598-49,176,486 (from NCBI)

This gene has 5 transcripts (splice variants), 125 orthologues, 54 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 31.3), ovary (RPKM 23.4) and 23 other tissues.

Summary

This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. [provided by RefSeq, Sep 2010]

KLHDC8B Products (1)

mRNA	Protein	Name
NM_173546.3	NP_775817.1	kelch domain-containing protein 8B

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic cytokinetic process	IMP IMP: Inferred from mutant phenotype	20107318	GOA
involved in mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	20107318	GOA
involved in nuclear chromosome segregation	IMP IMP: Inferred from mutant phenotype	22988245	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cellularization cleavage furrow	IDA IDA: Inferred from direct assay	20107318	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20107318	GOA
located in intercellular bridge	IDA IDA: Inferred from direct assay	20107318	GOA
located in midbody	IDA IDA: Inferred from direct assay	20107318	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHDC8B Protein Structure

Kelch_3

Kelch_1

Kelch_4

Kelch_1

Kelch_6

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
kelch domain-containing protein 8B

Related Diseases

Diseases	Alias
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Hodgkin'S Lymphoma, Nodular Sclerosis	Classical Hodgkin Lymphoma, Nodular Sclerosis Classic Hodgkin Lymphoma, Nodular Sclerosis Type Nodular Sclerosis Hodgkin Lymphoma Hodgkin'S Disease, Nodular Sclerosis Hodgkin Disease, Nodular Sclerosis Hodgkin Lymphoma, Nodular Sclerosis Hodgkin Nodular Sclerosis
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07353	KLHDC8B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KLHDC8B	VGNC	VGNC:42444
Macaca mulatta	KLHDC8B	VGNC	VGNC:74142
Rattus norvegicus	KLHDC8B	RGD	RGD:1359445
Bos taurus	KLHDC8B	VGNC	VGNC:30640
Felis catus	KLHDC8B	VGNC	VGNC:63140
Mus musculus	KLHDC8B	MGD	MGI:1925517
Others	KLHDC8B	NCBI