Satb1 - special AT-rich sequence binding protein 1 Gene

Also Known as 2610306G12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20230

Summary

Enables several functions, including DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and chromatin binding activity. Acts upstream of or within several processes, including T cell activation; histone methylation; and negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nuclear matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SATB1 (SATB homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Satb1 Products (8)

mRNA	Protein	Name
NM_001163630.1	NP_001157102.1	DNA-binding protein SATB1 isoform 1
NM_001163631.1	NP_001157103.1	DNA-binding protein SATB1 isoform 1
NM_001163632.1	NP_001157104.1	DNA-binding protein SATB1 isoform 1
NM_001357636.1	NP_001344565.1	DNA-binding protein SATB1 isoform 2
NM_001357637.1	NP_001344566.1	DNA-binding protein SATB1 isoform 3
NM_001357638.1	NP_001344567.1	DNA-binding protein SATB1 isoform 1
NM_001357640.1	NP_001344569.1	DNA-binding protein SATB1 isoform 4
NM_009122.2	NP_033148.2	DNA-binding protein SATB1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8114718	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12692553	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	29924977	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	21930775	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	10716941	MGI
acts upstream of or within CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	10716941	MGI
acts upstream of or within T cell activation	IMP IMP: Inferred from mutant phenotype	10716941	MGI
acts upstream of or within activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	15814699	MGI
acts upstream of or within chromatin organization	IDA IDA: Inferred from direct assay	12692553	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	21930775	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	21930775	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15851481	MGI
acts upstream of or within reflex	IMP IMP: Inferred from mutant phenotype	10716941	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12692553	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	29924977	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	15851481	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	12692553	MGI
located in nuclear matrix	IDA IDA: Inferred from direct assay	15851481	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA-binding protein SATB1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W011725	N-6-Methyl-2-deoxyadenosine	Inhibitor	99.83%	Unkown
HY-RS12457	SATB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20101	Satb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26604	Satb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Satb1	NCBI	NCBI:6304