Scn10a - sodium channel, voltage-gated, type X, alpha Gene

Also Known as PN3; SNS; Nav1.8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20264

About Scn10a

Chromosome 9: 119,437,522-119,548,388 reverse strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 331 orthologues, 26 paralogues and is associated with 18 phenotypes. Biased expression in heart adult (RPKM 1.), CNS E18 (RPKM .5) and 9 other tissues.

Summary

Enables voltage-gated Sodium Channel activity. Acts upstream of or within cardiac conduction; regulation of atrial cardiac muscle cell membrane depolarization; and sodium ion transport. Located in C-fiber and plasma membrane. Is expressed in brain; ganglia; and heart. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Apr 2022]

Scn10a Products (2)

mRNA Protein Name
NM_009134.3 NP_033160.2 sodium channel protein type 10 subunit alpha isoform 2
NM_001205321.1 NP_001192250.1 sodium channel protein type 10 subunit alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
16029194 MGI
Biological Process GO Annotation Evidence References Source
involved in behavioral response to pain IMP
IMP: Inferred from mutant phenotype
24440715 MGI
acts upstream of or within cardiac conduction IMP
IMP: Inferred from mutant phenotype
20062061 MGI
involved in circadian rhythm IMP
IMP: Inferred from mutant phenotype
25101983 MGI
involved in detection of mechanical stimulus involved in sensory perception IMP
IMP: Inferred from mutant phenotype
25101983 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
19931571 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
16029194 MGI
acts upstream of or within regulation of atrial cardiac muscle cell membrane depolarization IMP
IMP: Inferred from mutant phenotype
20062061 MGI
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
16029194 MGI
Cellular Component GO Annotation Evidence References Source
located in C-fiber IDA
IDA: Inferred from direct assay
16029194 MGI
located in axon IDA
IDA: Inferred from direct assay
16029194 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16029194 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn10a Protein Structure

Ion_trans

Ion_trans: pfam00520 (128 - 405)

Ion_trans

Ion_trans: pfam00520 (662 - 892)

Na_trans_assoc

Na_trans_assoc: pfam06512 (902 - 1146)

Ion_trans

Ion_trans: pfam00520 (1150 - 1426)

Na_channel_gate

Na_channel_gate: cd13433 (1418 - 1470)

Ion_trans

Ion_trans: pfam00520 (1474 - 1731)

  • 0
  • 400
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  • 1200
  • 1600
  • 1957 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 10 subunit alpha

  • peripheral nerve sodium channel 3

  • sensory neuron sodium channel

  • sodium channel protein type X subunit alpha

  • voltage gated sodium channel

  • voltage-gated sodium channel subunit alpha Nav1.8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12519 SCN10A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12520 Scn10a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12521 Scn10a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn10a NCBI NCBI:6336