Scn3a - sodium channel, voltage-gated, type III, alpha Gene

Also Known as Gm1000; Nav1.3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20269

About Scn3a

Chromosome 2: 65,287,462-65,397,971 reverse strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 130 orthologues, 26 paralogues and is associated with 5 phenotypes. Biased expression in whole brain E14.5 (RPKM 13.5), CNS E18 (RPKM 13.4) and 6 other tissues.

Summary

Predicted to enable Calmodulin binding activity; sodium ion binding activity; and voltage-gated Sodium Channel activity. Predicted to be involved in several processes, including neuronal action potential; response to pyrethroid; and sodium ion transmembrane transport. Predicted to act upstream of or within regulation of ion transmembrane transport and sodium ion transport. Located in cytoplasm and membrane. Is expressed in cerebral cortex; heart; sciatic nerve; sympathetic ganglion; and telencephalon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 62 and focal epilepsy. Orthologous to human SCN3A (sodium voltage-gated channel alpha subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Scn3a Products (7)

mRNA Protein Name
NM_001355171.1 NP_001342100.1 sodium channel protein type 3 subunit alpha isoform 7
NM_001355169.1 NP_001342098.1 sodium channel protein type 3 subunit alpha isoform 4
NM_001355168.1 NP_001342097.1 sodium channel protein type 3 subunit alpha isoform 3
NM_018732.3 NP_061202.3 sodium channel protein type 3 subunit alpha isoform 5
NM_001355166.1 NP_001342095.1 sodium channel protein type 3 subunit alpha isoform 1
NM_001355170.1 NP_001342099.1 sodium channel protein type 3 subunit alpha isoform 6
NM_001355167.1 NP_001342096.1 sodium channel protein type 3 subunit alpha isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in behavioral response to pain IMP
IMP: Inferred from mutant phenotype
24440715 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
17537961 MGI
located in sarcoplasm IDA
IDA: Inferred from direct assay
15746173 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn3a Protein Structure

Ion_trans

Ion_trans: pfam00520 (126 - 433)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (557 - 692)

Ion_trans

Ion_trans: pfam00520 (741 - 954)

Na_trans_assoc

Na_trans_assoc: pfam06512 (980 - 1183)

Ion_trans

Ion_trans: pfam00520 (1188 - 1460)

Na_channel_gate

Na_channel_gate: cd13433 (1452 - 1504)

Ion_trans

Ion_trans: pfam00520 (1508 - 1764)

  • 0
  • 400
  • 800
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  • 1600
  • 1979 a.a.
Protein Preferred Names Protein Names

sodium channel protein type 3 subunit alpha

  • sodium channel protein brain III subunit alpha

  • sodium channel protein type III subunit alpha

  • sodium channel, voltage-gated, type III, alpha polypeptide

  • voltage-gated sodium channel subtype III

  • voltage-gated sodium channel subunit alpha Nav1.3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12533 SCN3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12534 Scn3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12535 Scn3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scn3a NCBI NCBI:6328