Sgpl1 - sphingosine phosphate lyase 1 Gene

Also Known as Spl; S1PL; D10Xrf456

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20397

Summary

Predicted to enable sphinganine-1-phosphate aldolase activity. Acts upstream of or within several processes, including animal organ development; cellular hormone metabolic process; and face morphogenesis. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sgpl1 Products (3)

mRNA Protein Name
NM_001316673.1 NP_001303602.1 sphingosine-1-phosphate lyase 1
NM_001316674.1 NP_001303603.1 sphingosine-1-phosphate lyase 1
NM_009163.4 NP_033189.2 sphingosine-1-phosphate lyase 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within Leydig cell differentiation IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within androgen metabolic process IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within estrogen metabolic process IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within excretion IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within fibroblast migration IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within luteinization IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
28165339 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingosine-1-phosphate lyase 1

  • SP-lyase 1

  • SPL 1

  • sphingosine-1-phosphate aldolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D2284 SGPL1 fluorogenic substrate 98.81% Unkown
HY-RS12809 SGPL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21755 Sgpl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28273 Sgpl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sgpl1 NCBI NCBI:8879