St3gal1 - ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Gene

Also Known as Siat4; Siat4a; ST3GalI; St3gal-1; 5330418N22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20442

Summary

Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in several processes, including ganglioside biosynthetic process via lactosylceramide; memory B cell differentiation; and negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process. Acts upstream of or within protein glycosylation and protein phosphorylation. Predicted to be located in Golgi medial cisterna membrane; Golgi trans cisterna membrane; and trans-Golgi network membrane. Is expressed in several structures, including alimentary system; ear; hemolymphoid system; integumental system; and nervous system. Orthologous to human ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

St3gal1 Products (4)

mRNA Protein Name
NM_001412635.1 NP_001399564.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
NM_001412636.1 NP_001399565.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
NM_001412637.1 NP_001399566.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
NM_009177.5 NP_033203.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
IDA: Inferred from direct assay
8144500 MGI
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IMP
IMP: Inferred from mutant phenotype
12068010 MGI
Biological Process GO Annotation Evidence References Source
involved in ganglioside biosynthetic process via lactosylceramide IDA
IDA: Inferred from direct assay
8144500 MGI
involved in memory B cell differentiation IMP
IMP: Inferred from mutant phenotype
10755614 MGI
involved in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
10755614 MGI
acts upstream of or within protein glycosylation IDA
IDA: Inferred from direct assay
8375377 MGI
acts upstream of or within protein glycosylation IMP
IMP: Inferred from mutant phenotype
12068010 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
9184827 MGI
involved in protein sialylation IDA
IDA: Inferred from direct assay
8144500 MGI
involved in protein sialylation IMP
IMP: Inferred from mutant phenotype
10755614 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

  • CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase

  • Gal beta1,3 GalNAc alpha2,3 sialyltransferase

  • SIAT4-A

  • ST3GAL-I sialyltransferase

  • ST3Gal I

  • ST3GalA.1

  • ST3O

  • alpha 2,3-ST 1

  • beta-galactoside alpha-2,3-sialyltransferase 1

  • gal-NA

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163548 SPP-002 Inhibitor 98.0% Unkown
HY-172888 SPP-037 Inhibitor / Unkown
HY-E70298 ST3 β-Gal α-2,3-Sialyltransferase 1 / Unkown
HY-RS13846 ST3GAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20651 St3gal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27162 St3gal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens St3gal1 NCBI NCBI:6482