Slc4a1 - solute carrier family 4 (anion exchanger), member 1 Gene

Also Known as Ae1; CD233; Empb3; l11Jus51

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20533

Summary

Enables anion transmembrane transporter activity; ankyrin binding activity; and Hemoglobin binding activity. Involved in chloride transport. Acts upstream of or within several processes, including bicarbonate transport; erythrocyte development; and negative regulation of glycolytic process through fructose-6-phosphate. Located in basolateral plasma membrane; cortical cytoskeleton; and cytoplasmic side of plasma membrane. Is expressed in several structures, including blood; blood vessel; liver; lung; and metanephros. Used to study hereditary spherocytosis type 4 and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a1 Products (1)

mRNA	Protein	Name
NM_011403.2	NP_035533.1	band 3 anion transport protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ankyrin binding	IPI IPI: Inferred from physical interaction	17715300	MGI
enables bicarbonate transmembrane transporter activity	IDA IDA: Inferred from direct assay	23878365	MGI
enables chloride transmembrane transporter activity	IDA IDA: Inferred from direct assay	17690150	MGI
enables chloride:bicarbonate antiporter activity	IMP IMP: Inferred from mutant phenotype	17409310	MGI
enables hemoglobin binding	IDA IDA: Inferred from direct assay	22452706	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11591653	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within bicarbonate transport	IDA IDA: Inferred from direct assay	23878365	MGI
acts upstream of or within blood coagulation	IMP IMP: Inferred from mutant phenotype	9716609	MGI
involved in chloride transport	IDA IDA: Inferred from direct assay	17690150	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	17715300	MGI
acts upstream of or within negative regulation of glycolytic process through fructose-6-phosphate	IMP IMP: Inferred from mutant phenotype	18698006	MGI
acts upstream of or within negative regulation of oxidoreductase activity	IMP IMP: Inferred from mutant phenotype	18698006	MGI
acts upstream of or within negative regulation of urine volume	IMP IMP: Inferred from mutant phenotype	17409310	MGI
acts upstream of or within pH elevation	IMP IMP: Inferred from mutant phenotype	17409310	MGI
acts upstream of or within plasma membrane phospholipid scrambling	IMP IMP: Inferred from mutant phenotype	9716609	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	18698006	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12388412	MGI
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	18723693	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	17715300	MGI
located in membrane	IDA IDA: Inferred from direct assay	17690150	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	23878365	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
band 3 anion transport protein	AE 1 MEB3 anion exchange protein 1 anion exchanger 1 erythrocyte membrane protein band 3 solute carrier family 4 member 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13265	SLC4A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20193	Slc4a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26698	Slc4a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc4a1	NCBI	NCBI:6521