Sorl1 - sortilin-related receptor, LDLR class A repeats-containing Gene

Also Known as LR11; SorLA; gp250; mSorLA; 2900010L19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20660

Summary

Predicted to enable several functions, including low-density lipoprotein particle binding activity; peptide binding activity; and small GTPase binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of protein metabolic process; and regulation of signal transduction. Located in extracellular space; nuclear envelope lumen; and perinucleolar compartment. Is integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sorl1 Products (2)

mRNA Protein Name
NM_001357261.1 NP_001344190.1 sortilin-related receptor isoform 2
NM_011436.4 NP_035566.2 sortilin-related receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aspartic-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
18362153 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16407538 MGI
Biological Process GO Annotation Evidence References Source
involved in adaptive thermogenesis IMP
IMP: Inferred from mutant phenotype
26584636 MGI
involved in diet induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26584636 MGI
involved in endosome to plasma membrane protein transport IDA
IDA: Inferred from direct assay
27322061 MGI
involved in insulin receptor recycling IDA
IDA: Inferred from direct assay
27322061 MGI
involved in negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
26584636 MGI
involved in negative regulation of amyloid precursor protein catabolic process IMP
IMP: Inferred from mutant phenotype
18362153 MGI
involved in negative regulation of amyloid-beta formation IMP
IMP: Inferred from mutant phenotype
18362153 MGI
involved in negative regulation of neurofibrillary tangle assembly IMP
IMP: Inferred from mutant phenotype
22986780 MGI
involved in negative regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
18362153 MGI
involved in negative regulation of triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
27322061 MGI
involved in positive regulation of adipose tissue development IMP
IMP: Inferred from mutant phenotype
27322061 MGI
involved in positive regulation of glial cell-derived neurotrophic factor production IMP
IMP: Inferred from mutant phenotype
21994944 MGI
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27322061 MGI
involved in protein retention in Golgi apparatus IMP
IMP: Inferred from mutant phenotype
18362153 MGI
involved in protein targeting IDA
IDA: Inferred from direct assay
27322061 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11082041 MGI
located in membrane IDA
IDA: Inferred from direct assay
11082041 MGI
located in nuclear envelope lumen IDA
IDA: Inferred from direct assay
18362153 MGI
located in perinucleolar compartment IDA
IDA: Inferred from direct assay
11082041 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sortilin-related receptor

  • LDLR relative with 11 ligand-binding repeats

  • low-density lipoprotein receptor relative with 11 ligand-binding repeats

  • sorLA-1

  • sorting protein-related receptor containing LDLR class A repeats

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13574 SORL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21763 Sorl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sorl1 NCBI NCBI:6653