Sox10 - SRY (sex determining region Y)-box 10 Gene

Also Known as gt; Dom; Sox21

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20665

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; neural crest cell migration; and neurogenesis. Acts upstream of or within several processes, including lacrimal gland development; melanocyte differentiation; and nervous system development. Located in cytoplasm and nucleus. Is extrinsic component of mitochondrial outer membrane. Is expressed in several structures, including alimentary system; genitourinary system; inner ear; mesenchyme derived from neural crest; and nervous system. Used to study Kallmann syndrome; PCWH syndrome; and Waardenburg syndrome type 4C. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Apr 2022]

Sox10 Products (1)

mRNA Protein Name
NM_011437.1 NP_035567.1 transcription factor SOX-10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
24204311 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
24204311 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
17084361 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15729346 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15102707 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15729346 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19304657 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
17084361 MGI
enables transcription factor binding IDA
IDA: Inferred from direct assay
19179536 MGI
enables transcription factor binding IGI
IGI: Inferred from genetic interaction
23575864 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
11799060 MGI
acts upstream of or within cell maturation IGI
IGI: Inferred from genetic interaction
15102707 MGI
acts upstream of or within cell maturation IMP
IMP: Inferred from mutant phenotype
15102707 MGI
involved in central nervous system myelination IMP
IMP: Inferred from mutant phenotype
24204311 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
16790476 MGI
acts upstream of or within digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
6512238 MGI
acts upstream of or within enteric nervous system development IMP
IMP: Inferred from mutant phenotype
6512238 MGI
involved in enteric nervous system development IMP
IMP: Inferred from mutant phenotype
15572147 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
16790476 MGI
acts upstream of or within lacrimal gland development IMP
IMP: Inferred from mutant phenotype
24924191 MGI
acts upstream of or within melanocyte differentiation IMP
IMP: Inferred from mutant phenotype
16790476 MGI
acts upstream of or within morphogenesis of a branching epithelium IGI
IGI: Inferred from genetic interaction
24924191 MGI
acts upstream of or within morphogenesis of a branching epithelium IMP
IMP: Inferred from mutant phenotype
24924191 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15572147 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17875931 MGI
involved in neural crest cell migration IMP
IMP: Inferred from mutant phenotype
15572147 MGI
acts upstream of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
16857183 MGI
involved in oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
24204311 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16790476 MGI
involved in oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
24204311 MGI
acts upstream of or within peripheral nervous system development IGI
IGI: Inferred from genetic interaction
16790476 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21610032 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17084361 MGI
involved in positive regulation of gliogenesis IMP
IMP: Inferred from mutant phenotype
15572147 MGI
acts upstream of or within positive regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
16857183 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19304657 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15729346 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16857183 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16857183 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19304657 MGI
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
19304657 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15572147 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-10

  • SRY-box containing gene 10

  • dominant megacolon

  • transcription factor SOX-M

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179505 OPN-9652 Inhibitor 98.84% Unkown
HY-RS13583 SOX10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179559 OPN-9643 Inhibitor / Unkown
HY-186262 SH-0029 Inhibitor / Unkown
HY-RS18684 Sox10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25170 Sox10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox10 NCBI NCBI:6663