Spam1 - sperm adhesion molecule 1 Gene

Also Known as Ph-20

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20690

Summary

Enables hyalurononglucosaminidase activity. Acts upstream of or within single fertilization. Located in acrosomal vesicle; external side of plasma membrane; and membrane raft. Orthologous to human SPAM1 (sperm adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Spam1 Products (2)

mRNA Protein Name
NM_001079875.2 NP_001073344.1 hyaluronidase PH-20 precursor
NM_009241.3 NP_033267.2 hyaluronidase PH-20 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hyalurononglucosaminidase activity IDA
IDA: Inferred from direct assay
16330764 MGI
enables hyalurononglucosaminidase activity IMP
IMP: Inferred from mutant phenotype
12065596 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within single fertilization IMP
IMP: Inferred from mutant phenotype
12065596 MGI
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
16330764 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
16925524 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
19144954 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16330764 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hyaluronidase PH-20

  • hyal-PH20

  • hyaluronoglucosaminidase PH-20

  • sperm surface protein PH-20

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991212 Berahyaluronidase alfa Degrader 99.01% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13628 SPAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22821 Spam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29336 Spam1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spam1 NCBI NCBI:6677