SPAM1 - sperm adhesion molecule 1 Gene

Also Known as HYA1; PH20; HYAL1; HYAL3; HYAL5; PH-20; SPAG15; HEL-S-96n

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6677

About SPAM1

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:123,925,241-123,971,414 (from NCBI)

This gene has 7 transcripts (splice variants), 239 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 5.9).

Summary

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

SPAM1 Products (5)

mRNA Protein Name
NM_001174044.2 NP_001167515.1 hyaluronidase PH-20 isoform 2
NM_001174045.2 NP_001167516.1 hyaluronidase PH-20 isoform 2
NM_001174046.2 NP_001167517.1 hyaluronidase PH-20 isoform 2
NM_003117.5 NP_003108.2 hyaluronidase PH-20 isoform 1
NM_153189.3 NP_694859.1 hyaluronidase PH-20 isoform 2

SPAM1 Protein Structure

Glyco_hydro_56

Glyco_hydro_56: Hyaluronidase (39 - 374)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 509 a.a.
Protein Preferred Names Protein Names

hyaluronidase PH-20

  • PH-20 hyaluronidase

Recombinant SPAM1 Proteins

Cat. No. Product Name Accession Purity
HY-P78780 PH20/SPAM1 Protein, Human (Active, HEK293, His) P38567-1 (L36-Y482) ≥ 95%, as determined by reducing SDS-PAGE.

SPAM1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86254 SPAM1 Antibody (YA5946) WB, IHC-P Human

Related Diseases

Diseases Alias
Mucopolysaccharidosis, Type Ix

  • Mucopolysaccharidosis Type Ix

  • Hyaluronidase Deficiency

  • MPS9

  • Mps Ix

  • Mucopolysaccharidosis Ix

  • Mpsix

  • Mucopolysaccharidosis Type 9

  • Mucopolysaccharidosis 9
Idiopathic Corneal Edema
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Mucopolysaccharidosis, Type Ivb

  • Mucopolysaccharidosis Type Ivb

  • Mps Ivb

  • MPS4B

  • Morquio Syndrome B

  • Beta-D-Galactosidase Deficiency

  • Morquio Disease Type B

  • Mps 4b

  • Mucopolysaccharidosis Type 4b

  • Mpsivb

  • Morquio Disease, Type B

  • Mucopolysaccharidosis Type Iv-B

  • Mucopolysaccharidosis 4b

  • Morquio'S Syndrome B

  • Mps-Ivb
Mucopolysaccharidosis, Type Iiid

  • Mucopolysaccharidosis Type Iiid

  • MPS3D

  • Mps Iiid

  • N-Acetylglucosamine-6-Sulfatase Deficiency

  • Sanfilippo Syndrome D

  • Gns Deficiency

  • Mucopolysaccharidosis Type 3d

  • Sanfilippo Syndrome Type D

  • Glucosamine N-Acetyl-6-Sulfatase Deficiency

  • Mpsiiid

  • Mps 3d

  • Mucopoly-Saccharidosis Type 3d

  • N-Acetylglucosamine-6-Sulfate Sulfatase Deficiency

  • Mps Iii-D

  • Mucopolysaccharidosis 3d

  • Sanfilippo D Syndrome

  • Mps Iii D
Mucopolysaccharidosis-Plus Syndrome

  • Mucopolysaccharidosis

  • Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders

  • MPSPS

  • Mucopolysaccharidoses

  • Mps

  • Mucopolysaccharidosis-Like Plus Disease

  • Disorders Of Glycosaminoglycan Metabolism
Mucopolysaccharidosis, Type Iva

  • Mps Iva

  • Galns Deficiency

  • MPS4A

  • Morquio A Disease

  • Galactosamine-6-Sulfatase Deficiency

  • Morquio Syndrome A

  • Mucopolysaccharidosis Iva

  • Mucopolysaccharidosis Type Iva

  • Mpsiva

  • Morquio Disease Type A

  • Mucopolysaccharidosis Type 4a

  • N-Acetylgalactosamine-6-Sulfate Sulfatase Deficiency

  • Morquio Syndrome Type A

  • Mps 4a

  • Morquio Disease, Type A

  • Mucopolysaccharidosis 4a

  • Morquio'S Syndrome A

  • Mps Iv A

  • Mucopolysaccharidosis Iv

  • Mucopolysaccharidosis, Mps-Iv-A
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta SPAM1 VGNC VGNC:77853
Canis familiaris SPAM1 VGNC VGNC:46700
Rattus norvegicus SPAM1 RGD RGD:620547
Felis catus SPAM1 VGNC VGNC:65600
Others SPAM1 NCBI