Srebf1 - sterol regulatory element binding transcription factor 1 Gene

Also Known as ADD1; SREBP1; bHLHd1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20787

Summary

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene. [provided by RefSeq, Nov 2017]

Srebf1 Products (4)

mRNA Protein Name
NM_001313979.1 NP_001300908.1 sterol regulatory element-binding protein 1 isoform b
NM_001358314.1 NP_001345243.1 sterol regulatory element-binding protein 1 isoform c
NM_001358315.1 NP_001345244.1 sterol regulatory element-binding protein 1 isoform d
NM_011480.4 NP_035610.1 sterol regulatory element-binding protein 1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11829742 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8833906 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
21531336 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16443825 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15637161 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14654692 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19244231 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14654692 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
16407292 MGI
acts upstream of cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
9329978 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
19786558 MGI
acts upstream of or within fat cell differentiation IMP
IMP: Inferred from mutant phenotype
22331133 MGI
acts upstream of or within insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
17074803 MGI
acts upstream of insulin secretion IMP
IMP: Inferred from mutant phenotype
16890542 MGI
involved in lipid biosynthetic process IDA
IDA: Inferred from direct assay
21459323 MGI
acts upstream of or within mRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22331133 MGI
acts upstream of or within negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
16890542 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17074803 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17636037 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11090130 MGI
involved in positive regulation of cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
8833906 MGI
acts upstream of or within positive regulation of cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
9329978 MGI
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
21531336 MGI
involved in positive regulation of lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
21531336 MGI
involved in positive regulation of miRNA transcription IDA
IDA: Inferred from direct assay
23823476 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9329978 MGI
involved in positive regulation of triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
19244231 MGI
acts upstream of or within positive regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
16046411 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12242332 MGI
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21459323 MGI
acts upstream of or within regulation of fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
19564420 MGI
acts upstream of or within regulation of heart rate by chemical signal IMP
IMP: Inferred from mutant phenotype
18060044 MGI
acts upstream of or within regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18178930 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8833906 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21531336 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
18178930 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16890542 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16100574 MGI
located in membrane IDA
IDA: Inferred from direct assay
11090130 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11090130 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sterol regulatory element-binding protein 1

  • adipocyte determination- and differentiation-dependent factor 1

Srebf1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Srebf1 Q9WTN3 Sirt1 Mus musculus Q923E4
Anti Bait CoIP
20817729
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1856 Proinsulin C-peptide (human) Inhibitor 99.54% Unkown
HY-50670 DGAT-1 inhibitor 2 95.33% Unkown
HY-RS13757 SREBF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184415 Syk/HDAC6-IN-1 / Unkown
HY-RS17721 Srebf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24186 Srebf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29460 SREBF1 Pig Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srebf1 NCBI NCBI:6720