Bhlhe40 - basic helix-loop-helix family, member e40 Gene

Also Known as CR8; Dec1; Bhlhb2; Clast5; Sharp2; Stra13; Stra14; C130042M06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20893

Summary

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Bhlhe40 Products (1)

mRNA Protein Name
NM_011498.4 NP_035628.1 class E basic helix-loop-helix protein 40

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12297495 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15147242 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15147242 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
12397359 MGI
enables MRF binding IDA
IDA: Inferred from direct assay
17487425 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15147242 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
17487425 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12297495 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18411297 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
19786558 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: Inferred from mutant phenotype
18411297 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12297495 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
30012868 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
30012868 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12297495 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

class E basic helix-loop-helix protein 40

  • E47 interaction protein 1

  • basic helix-loop-helix domain containing, class B2

  • class B basic helix-loop-helix protein 2

  • cytokine response gene 8

  • differentially expressed in chondrocytes protein 1

  • eip1 (E47 interaction protein 1)

  • stimulated by retinoic

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01493 BHLHE40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18433 Bhlhe40 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24914 Bhlhe40 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bhlhe40 NCBI NCBI:8553