Syp - synaptophysin Gene

Also Known as Syn; p38; A230093K24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20977

Summary

Enables SH2 domain binding activity and identical protein binding activity. Involved in modulation of chemical synaptic transmission and synaptic vesicle endocytosis. Acts upstream of or within cellular response to organic substance. Located in several cellular components, including neuromuscular junction; presynaptic membrane; and synaptic vesicle membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in diaphragm; gut; nervous system; sensory organ; and skeletal muscle. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Apr 2022]

Syp Products (1)

mRNA Protein Name
NM_009305.2 NP_033331.2 synaptophysin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH2 domain binding IDA
IDA: Inferred from direct assay
18706977 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
18706977 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18706977 MGI
Biological Process GO Annotation Evidence References Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
10595519 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
10595519 MGI
involved in regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
10595519 MGI
involved in regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
10595519 MGI
involved in regulation of synaptic vesicle priming IDA
IDA: Inferred from direct assay
31090538 MGI
involved in regulation of synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
31090538 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
10595519 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
10595519 MGI
located in excitatory synapse IDA
IDA: Inferred from direct assay
16980967 MGI
located in membrane IDA
IDA: Inferred from direct assay
15748150 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
20826656 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21307259 MGI
located in neuron projection IMP
IMP: Inferred from mutant phenotype
21664258 MGI
located in neuron projection terminus IDA
IDA: Inferred from direct assay
12074840 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17046993 MGI
located in presynapse IDA
IDA: Inferred from direct assay
31787876 MGI
is active in presynaptic active zone IDA
IDA: Inferred from direct assay
21664258 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
15328414 MGI
located in synapse IDA
IDA: Inferred from direct assay
10712642 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
9364068 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
12805290 MGI
located in terminal bouton IDA
IDA: Inferred from direct assay
20203623 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptophysin

  • BM89 antigen

  • Syp I

  • major synaptic vesicle protein p38

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100693 SYP-5 Inhibitor 99.21% Unkown
HY-136356 Triclopyricarb Inhibitor / Unkown
HY-136915 Pyrisoxazole Inhibitor / Unkown
HY-RS14102 SYP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122480 Fenaminstrobin Inhibitor / Unkown
HY-17521 Flumorph Inhibitor 99.57% Unkown
HY-RS16733 Ptpn11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20686 Syp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27197 Syp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syp NCBI NCBI:6855