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T - brachyury, T-box transcription factor T Gene

Also Known as Lr; T1; Bra; Low; Tl2; Tl3; cou; Tbxt; me75; D17Mit170

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20997

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of gene expression. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including egg cylinder; embryo mesenchyme; future spinal cord; heart; and mesoderm. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T). [provided by Alliance of Genome Resources, Apr 2022]

T Products (1)

mRNA	Protein	Name
NM_009309.2	NP_033335.1	T-box transcription factor T

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7588606	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17584735	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	22164283	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16801560	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7588606	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	16835439	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15384171	MGI
acts upstream of or within bone morphogenesis	IGI IGI: Inferred from genetic interaction	11071760	MGI
involved in cardiac muscle cell myoblast differentiation	IMP IMP: Inferred from mutant phenotype	21632880	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16835439	MGI
acts upstream of or within determination of heart left/right asymmetry	IMP IMP: Inferred from mutant phenotype	10349618	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	8293872	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	8293872	MGI
acts upstream of or within mesoderm migration involved in gastrulation	IMP IMP: Inferred from mutant phenotype	7720590	MGI
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	22164283	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22164283	MGI
acts upstream of or within neural plate morphogenesis	IMP IMP: Inferred from mutant phenotype	15384171	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	16835439	MGI
acts upstream of or within notochord development	IMP IMP: Inferred from mutant phenotype	8155581	MGI
acts upstream of or within notochord formation	IMP IMP: Inferred from mutant phenotype	7589801	MGI
acts upstream of or within penetration of zona pellucida	IMP IMP: Inferred from mutant phenotype	7883069	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16835439	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16801560	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21632880	MGI
acts upstream of or within post-anal tail morphogenesis	IGI IGI: Inferred from genetic interaction	11071760	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	924142	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7588606	MGI
acts upstream of or within reproductive process	IMP IMP: Inferred from mutant phenotype	924142	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	8293872	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16801560	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	16835439	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	22164283	MGI
located in chromatin	IMP IMP: Inferred from mutant phenotype	21632880	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16835439	MGI
located in nucleus	IDA IDA: Inferred from direct assay	7588606	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
T-box transcription factor T	brachyury brachyury protein brachyury-like 2 brachyury-like 3 low ratio protein T

T Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Tbxt	P20293	Mixl1	Mus musculus	Q9WUI0	Pull Down	22164283
Intra	Tbxt	P20293	Mixl1	Mus musculus	Q9WUI0	Anti Tag CoIP	22164283

Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species	Symbol	Source
Canis familiaris	T	NCBI
Felis catus	T	NCBI
Macaca fascicularis	T	NCBI
Canis lupus familiaris	T	NCBI
Susscrofa domestica	T	NCBI
Leporidae	T	NCBI
Rattus norvegicus	T	NCBI
Macaca mulatta	T	NCBI