Trib1 - tribbles pseudokinase 1 Gene

Also Known as Trb1; TRB-1; A530090O15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 211770

Summary

Enables ubiquitin protein Ligase binding activity and ubiquitin-protein transferase regulator activity. Involved in several processes, including negative regulation of DNA-binding transcription factor activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of myeloid leukocyte differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart valve; and integumental system. Orthologous to human TRIB1 (tribbles pseudokinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Trib1 Products (1)

mRNA Protein Name
NM_144549.4 NP_653132.1 tribbles homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17724128 MGI
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
20410507 MGI
enables ubiquitin-protein transferase regulator activity IDA
IDA: Inferred from direct assay
20410507 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17724128 MGI
involved in negative regulation of neutrophil differentiation IMP
IMP: Inferred from mutant phenotype
23515163 MGI
involved in positive regulation of eosinophil differentiation IMP
IMP: Inferred from mutant phenotype
23515163 MGI
involved in positive regulation of macrophage differentiation IMP
IMP: Inferred from mutant phenotype
23515163 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20410507 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17724128 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tribbles homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15015 TRIB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22878 Trib1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29392 Trib1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trib1 NCBI NCBI:10221