Prdm9 - PR domain containing 9 Gene

Also Known as Rcr1; Dsbc1; repro7; Meisetz; PRDM9-B; G1-419-29

Species: Mus musculus

Gene Type: protein coding

Gene ID: 213389

Summary

Enables DNA binding activity; histone-lysine N-methyltransferase activity; and protein homodimerization activity. Involved in several processes, including gamete generation; histone lysine methylation; and meiosis I. Acts upstream of or within several processes, including histone methylation; positive regulation of meiotic nuclear division; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in embryo and head. Orthologous to human PRDM9 (PR/SET domain 9). [provided by Alliance of Genome Resources, Apr 2022]

Prdm9 Products (2)

mRNA	Protein	Name
NM_001361436.1	NP_001348365.1	histone-lysine N-methyltransferase PRDM9 isoform 2
NM_144809.3	NP_659058.3	histone-lysine N-methyltransferase PRDM9 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone H3K36 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	27362481	MGI
enables histone H3K4 methyltransferase activity	EXP EXP: Inferred from Experiment	16292313	MGI
enables histone H3K4 methyltransferase activity	IDA IDA: Inferred from direct assay	16292313	MGI
enables histone H3K4 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	16292313	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	27932493	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	24095733	MGI
enables recombination hotspot binding	IDA IDA: Inferred from direct assay	22028627	MGI
enables recombination hotspot binding	IMP IMP: Inferred from mutant phenotype	24151354	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22028627	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair involved in meiotic recombination	IMP IMP: Inferred from mutant phenotype	25894966	MGI
involved in female gamete generation	IMP IMP: Inferred from mutant phenotype	29478809	MGI
involved in homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	25894966	MGI
involved in male gamete generation	IMP IMP: Inferred from mutant phenotype	29478809	MGI
acts upstream of meiosis I	IMP IMP: Inferred from mutant phenotype	16292313	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	27932493	MGI
involved in positive regulation of fertilization	IMP IMP: Inferred from mutant phenotype	25894966	MGI
acts upstream of or within positive regulation of meiosis I	IMP IMP: Inferred from mutant phenotype	16292313	MGI
acts upstream of or within positive regulation of reciprocal meiotic recombination	IMP IMP: Inferred from mutant phenotype	20044538	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16292313	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16292313	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	19074312	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	29478809	MGI
located in nucleus	IDA IDA: Inferred from direct assay	25894966	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
histone-lysine N-methyltransferase PRDM9	PR domain zinc finger protein 9 PR domain-containing protein 9 VPR domain containing 9 [histone H3]-lysine36 N-trimethyltransferase PRDM9 [histone H3]-lysine4 N-trimethyltransferase PRDM9 [histone H3]-lysine9 N-trimethyltransferase PRDM9 [histone H4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114209	MRK-740	Inhibitor	99.13%	Unkown
HY-RS11073	PRDM9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176820	MRK-740-NC	Inhibitor	/	Unkown
HY-RS19230	Prdm9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25719	Prdm9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prdm9	NCBI	NCBI:56979