Tapbp - TAP binding protein Gene

Predicted to enable TAP complex binding activity; TAP1 binding activity; and TAP2 binding activity. Involved in peptide antigen stabilization. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent and defense response. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of MHC class I peptide loading complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; nervous system; notochord; and retina. Human ortholog(s) of this gene implicated in MHC class I deficiency and severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein). [provided by Alliance of Genome Resources, Apr 2022]