TAPBP - TAP binding protein Gene

Also Known as TPN; TAPA; TPSN; NGS17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6892

About TAPBP

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,299,694-33,314,078 (from NCBI)

This gene has 26 transcripts (splice variants), 1 gene allele, 210 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 38.1), appendix (RPKM 25.3) and 25 other tissues.

Summary

This gene encodes a Transmembrane Glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TAPBP Products (4)

mRNA	Protein	Name
NM_001410875.1	NP_001397804.1	tapasin isoform 4 precursor
NM_003190.5	NP_003181.3	tapasin isoform 1 precursor
NM_172208.3	NP_757345.2	tapasin isoform 2 precursor
NM_172209.3	NP_757346.2	tapasin isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables TAP complex binding	IDA IDA: Inferred from direct assay	17947644	GOA
enables TAP1 binding	IDA IDA: Inferred from direct assay	22638925	GOA
enables TAP1 binding	IPI IPI: Inferred from physical interaction	12047747	GOA
enables TAP2 binding	IDA IDA: Inferred from direct assay	22638925	GOA
enables TAP2 binding	IPI IPI: Inferred from physical interaction	12047747	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	17947644	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12213826	GOA
enables protein folding chaperone	IDA IDA: Inferred from direct assay	36104323	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in MHC class Ib protein complex assembly	IMP IMP: Inferred from mutant phenotype	12582157	GOA
involved in peptide antigen assembly with MHC class I protein complex	IDA IDA: Inferred from direct assay	10636848	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	17947644	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18802093	GOA
involved in regulation of protein complex stability	IDA IDA: Inferred from direct assay	18802093	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	11884415	GOA
part of MHC class I peptide loading complex	IDA IDA: Inferred from direct assay	17947644	GOA
part of Tapasin-ERp57 complex	IPI IPI: Inferred from physical interaction	19119025	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11884415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAPBP Protein Structure

C1-set

0
100
200
300
400
504 a.a.

Protein Preferred Names	Protein Names
tapasin	NGS-17

TAPBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAPBP	O15533	HLA-A	Homo sapiens	P01892	Anti Bait CoIP	24163410
Intra	TAPBP	O15533	HLA-A	Homo sapiens	P01892	Anti Tag CoIP	24163410
Intra	TAPBP	O15533	TAP1	Homo sapiens	Q03518	Anti Bait CoIP	12213826
Intra	TAPBP	O15533	TAP1	Homo sapiens	Q03518	Anti Bait CoIP	17055437
Intra	TAPBP	O15533	TAP1	Homo sapiens	Q03518	Anti Bait CoIP	19201886
Intra	TAPBP	O15533	TAP2	Homo sapiens	Q03519	Anti Bait CoIP	19201886
Intra	TAPBP	O15533	TAP2	Homo sapiens	Q03519	Anti Bait CoIP	12213826
Cross	TAPBP	O15533	bnl2a_ebvb9	Epstein-Barr virus	P0C739	Anti Bait CoIP	19201886

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TAPBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73619	Tapasin Protein, Human (HEK293, His)	O15533 (G21-V414)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Bare Lymphocyte Syndrome, Type I	Hla Class I Deficiency Mhc Class I Deficiency Bls, Type I Bare Lymphocyte Syndrome Type I Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency Blsi Mhc Class 1 Deficiency Major Histocompatibility Complex Class 1 Deficiency Bare Lymphocyte Syndrome 1 BLS1 Bls I Bls Type I Bl-1 Bare Lymphocyte Syndrome Type 1 Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1 Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens Bls - [Bare Lymphocyte Syndrome] Nos
Immunodeficiency By Defective Expression Of Mhc Class I	Bare Lymphocyte Syndrome Type 1 Mhc Class I Deficiency
Spondyloarthropathy 1	Ankylosing Spondylitis Spondyloarthropathy, Susceptibility To, 1 SPDA1 Marie-Strumpell Spondylitis Bechterew Syndrome Spa Spondylarthritis Ankylopoietica Reiter Syndrome Ankylosing Spondylitis, Susceptibility To Bekhterev Syndrome Bekhterev'S Disease Marie-Strumpell Disease Axial Spondylarthritis Bechterew Disease Marie-Struempell Disease Spondylitis Ankylopoietica Spondyloarthritis Spondyloarthritis Ankylopoietica Spas Ankylosing Spondylarthritis Psoriatic Arthritis Reactive Arthritis Rheumatoid Spondylitis Spondylitis Ankylosans Spondylitis Ankylosing Spondylitis, Ankylosing Spondylarthropathies Arthritis, Psoriatic Arthritis, Reactive
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14203	TAPBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18686	Tapbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25172	Tapbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TAPBP	MGD	MGI:1201689
Bos taurus	TAPBP	VGNC	VGNC:35599
Macaca mulatta	TAPBP	VGNC	VGNC:78098
Rattus norvegicus	TAPBP	RGD	RGD:3819
Canis familiaris	TAPBP	VGNC	VGNC:47106
Others	TAPBP	NCBI