Tcf3 - transcription factor 3 Gene

Also Known as A1; E12; E2A; E47; KA1; ME2; ALF2; Pan1; Pan2; VDIR; TCF-3; Tcfe2a; E12/E47; bHLHb21

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21423

Summary

Enables several functions, including E-box binding activity; protein heterodimerization activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in gastrulation; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including histone acetylation; immune system development; and regulation of gene expression. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex and nucleosome. Is expressed in several structures, including branchial arch; central nervous system; male reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal Cancer. Orthologous to human TCF3 (transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tcf3 Products (16)

mRNA Protein Name
NM_001164147.2 NP_001157619.1 transcription factor E2-alpha isoform 1
NM_001164148.2 NP_001157620.1 transcription factor E2-alpha isoform 2
NM_001164149.2 NP_001157621.1 transcription factor E2-alpha isoform 3
NM_001164150.2 NP_001157622.1 transcription factor E2-alpha isoform 4
NM_001164151.2 NP_001157623.1 transcription factor E2-alpha isoform 5
NM_001164152.2 NP_001157624.1 transcription factor E2-alpha isoform 6
NM_001164153.2 NP_001157625.1 transcription factor E2-alpha isoform 7
NM_001378903.1 NP_001365832.1 transcription factor E2-alpha isoform 9
NM_001378904.1 NP_001365833.1 transcription factor E2-alpha isoform 10
NM_001378905.1 NP_001365834.1 transcription factor E2-alpha isoform 11
NM_001378908.1 NP_001365837.1 transcription factor E2-alpha isoform 12
NM_001378910.1 NP_001365839.1 transcription factor E2-alpha isoform 13
NM_001378912.1 NP_001365841.1 transcription factor E2-alpha isoform 14
NM_001378913.1 NP_001365842.1 transcription factor E2-alpha isoform 15
NM_001378914.1 NP_001365843.1 transcription factor E2-alpha isoform 16
NM_011548.5 NP_035678.3 transcription factor E2-alpha isoform 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18361414 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11812799 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
12446773 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16673016 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12200424 MGI
contributes to E-box binding IDA
IDA: Inferred from direct assay
11812799 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
15226298 MGI
enables E-box binding IPI
IPI: Inferred from physical interaction
9545521 MGI
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18361414 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12446773 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
12446773 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11812799 MGI
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
9545521 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
18550854 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16140986 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
14757642 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10924525 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
18214987 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16428437 MGI
enables sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
12070084 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Peyer's patch development IGI
IGI: Inferred from genetic interaction
17452521 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
18958875 MGI
acts upstream of or within cell development IGI
IGI: Inferred from genetic interaction
17452521 MGI
acts upstream of or within chromatin remodeling IMP
IMP: Inferred from mutant phenotype
16428437 MGI
involved in gastrulation IGI
IGI: Inferred from genetic interaction
21828274 MGI
acts upstream of gene expression IMP
IMP: Inferred from mutant phenotype
18958875 MGI
acts upstream of or within immunoglobulin V(D)J recombination IMP
IMP: Inferred from mutant phenotype
16428437 MGI
acts upstream of or within lymphocyte differentiation IMP
IMP: Inferred from mutant phenotype
18958875 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: Inferred from genetic interaction
17452521 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
12070084 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18958875 MGI
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
18214987 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8760303 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11812799 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
8900141 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12446773 MGI
acts upstream of or within protein stabilization IDA
IDA: Inferred from direct assay
15322112 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15351717 MGI
acts upstream of or within regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
9676199 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19796622 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
16428437 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
16428437 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16428437 MGI
acts upstream of positive effect transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16673016 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
18361414 MGI
part of RNA polymerase II transcription regulator complex IMP
IMP: Inferred from mutant phenotype
30426815 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17507657 MGI
part of nucleosome IDA
IDA: Inferred from direct assay
16428437 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12200424 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
8760303 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
15314159 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor E2-alpha

  • immunoglobulin enhancer-binding factor E12/E47

  • transcription factor A1

  • transcription factor E2a

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14306 TCF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14309 TCF7L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183004 NCP26 / Unkown
HY-RS18501 Tcf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24983 Tcf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcf3 NCBI NCBI:6929