Terf1 - telomeric repeat binding factor 1 Gene

Also Known as Pin2; Trf1; Trbf1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21749

Summary

This gene encodes a protein that binds to repeats in telomeres to form a nucleoprotein complex that protects against the degradation of chromosomal ends. The encoded protein regulates the length of telomeres and is an integral structural component of the functional telomere. This protein is thought to play a role in spindle formation in Mitosis. Mutations in this gene are associated with bone marrow failure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

Terf1 Products (2)

mRNA Protein Name
NM_001286628.1 NP_001273557.1 telomeric repeat-binding factor 1 isoform 2
NM_009352.3 NP_033378.1 telomeric repeat-binding factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12676566 MGI
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
19854130 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within leptotene IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of or within meiotic telomere clustering IMP
IMP: Inferred from mutant phenotype
17010969 MGI
NOT involved in telomeric loop formation IMP
IMP: Inferred from mutant phenotype
24120135 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
15109494 MGI
part of nuclear telomere cap complex IDA
IDA: Inferred from direct assay
7502076 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17982445 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

telomeric repeat-binding factor 1

  • TTAGGG repeat-binding factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14372 TERF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20111 Terf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26615 Terf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Terf1 NCBI NCBI:7013