Tgfb3 - transforming growth factor, beta 3 Gene

Also Known as Tgfb-3; TGF-beta-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21809

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with Other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Homozygous knockout mice for this gene exhibit cleft palate, delayed pulmonary development and neonatal death. [provided by RefSeq, Aug 2016]

Tgfb3 Products (1)

mRNA Protein Name
NM_009368.3 NP_033394.2 transforming growth factor beta-3 proprotein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28912269 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
14697364 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
12815624 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
7848824 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
14729481 MGI
acts upstream of epithelial cell proliferation IDA
IDA: Inferred from direct assay
12815624 MGI
involved in face morphogenesis IEP
IEP: Inferred from expression pattern
18498113 MGI
acts upstream of filopodium assembly IMP
IMP: Inferred from mutant phenotype
16806156 MGI
acts upstream of or within positive effect gene expression IMP
IMP: Inferred from mutant phenotype
16245336 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
14729481 MGI
involved in lung alveolus development IMP
IMP: Inferred from mutant phenotype
7493022 MGI
acts upstream of or within mammary gland development IDA
IDA: Inferred from direct assay
1821856 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
12815624 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17159989 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17159989 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
14691138 MGI
involved in positive regulation of SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
14691138 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16806156 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
14691138 MGI
acts upstream of or within positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
16806156 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
21984612 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17159989 MGI
NOT involved in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: Inferred from mutant phenotype
19161227 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
16245336 MGI
involved in secondary palate development IMP
IMP: Inferred from mutant phenotype
7493021 MGI
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14691138 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
10521784 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transforming growth factor beta-3 proprotein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14442 TGFB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174532 Human TGFB3 mRNA / Unkown
HY-RS16996 Tgfb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23439 Tgfb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfb3 NCBI NCBI:7043