2. Gene
  3. Tgfbr1 - transforming growth factor, beta receptor I Gene

Tgfbr1 - transforming growth factor, beta receptor I Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ALK5; ESK2; Alk-5; TGFR-1; TbetaRI; TbetaR-I

Gene ID: 21812 | Gene type: protein coding

About Tgfbr1

Chromosome 4: 47,353,222-47,414,931 forward strand.GRCm39:CM000997.3

This gene has 5 transcripts (splice variants), 236 orthologues, 11 paralogues and is associated with 33 phenotypes. Broad expression in CNS E11.5 (RPKM 19.6), placenta adult (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and Apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Tgfbr1 Products(3)

mRNA Protein Name
NM_001312868.1 NP_001299797.1 TGF-beta receptor type-1 isoform 2 precursor
NM_009370.3 NP_033396.1 TGF-beta receptor type-1 isoform 1 precursor
NM_001312869.1 NP_001299798.1 TGF-beta receptor type-1 isoform 3

Tgfbr1 Protein Structure

Activin_recp

Activin_recp: pfam01064 (29 - 105)

TGF_beta_GS

TGF_beta_GS: pfam08515 (175 - 202)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (208 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

TGF-beta receptor type-1

TGF-beta receptor type I

transforming growth factor-beta receptor type I

Recombinant Tgfbr1 Proteins

Cat. No. Product Name Accession Purity
HY-P72454 TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc) Q64729 (L30-E125) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136244 PF-06952229 Inhibitor 99.92% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122856 AZ12601011 Inhibitor 99.88% Unkown
HY-123900 AZ12799734 Inhibitor 98.07% Unkown
HY-129171 TGFBR1-IN-1 Inhibitor / Unkown
HY-RS14444 TGFBR1 Human Pre-designed siRNA Set A / Unkown
HY-RS14445 Tgfbr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14446 TGFBR1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfbr1 NCBI NCBI:7046