Tgfbr1 - transforming growth factor, beta receptor I Gene

Also Known as ALK5; ESK2; Alk-5; TGFR-1; TbetaRI; TbetaR-I

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21812

About Tgfbr1

Chromosome 4: 47,353,222-47,414,931 forward strand.GRCm39:CM000997.3

This gene has 5 transcripts (splice variants), 236 orthologues, 11 paralogues and is associated with 33 phenotypes. Broad expression in CNS E11.5 (RPKM 19.6), placenta adult (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a member of the transforming growth factor beta (TGF-beta) receptor family of proteins. These proteins comprise one component of the TGF-beta signaling pathway, which transduces extracellular signals into gene expression changes to regulate a wide range of cellular responses, including proliferation, migration, differentiation and Apoptosis. Homozygous knockout mice for this gene exhibit impaired angiogenesis and embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Tgfbr1 Products (3)

mRNA Protein Name
NM_001312868.1 NP_001299797.1 TGF-beta receptor type-1 isoform 2 precursor
NM_009370.3 NP_033396.1 TGF-beta receptor type-1 isoform 1 precursor
NM_001312869.1 NP_001299798.1 TGF-beta receptor type-1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SMAD binding IDA
IDA: Inferred from direct assay
12773577 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12773577 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
25065622 MGI
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
17878231 MGI
enables transforming growth factor beta receptor activity IDA
IDA: Inferred from direct assay
15820682 MGI
enables transforming growth factor beta receptor activity IGI
IGI: Inferred from genetic interaction
17878231 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
11285230 MGI
involved in angiogenesis involved in coronary vascular morphogenesis IMP
IMP: Inferred from mutant phenotype
18718461 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
16845371 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16806156 MGI
acts upstream of or within artery morphogenesis IMP
IMP: Inferred from mutant phenotype
17078885 MGI
acts upstream of or within blastocyst development IDA
IDA: Inferred from direct assay
9921650 MGI
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
19494318 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
15993878 MGI
involved in coronary artery morphogenesis IMP
IMP: Inferred from mutant phenotype
18718461 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
14729481 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
16806156 MGI
acts upstream of or within endothelial cell migration IMP
IMP: Inferred from mutant phenotype
11285230 MGI
acts upstream of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
21832243 MGI
involved in epicardium morphogenesis IMP
IMP: Inferred from mutant phenotype
18718461 MGI
acts upstream of filopodium assembly IMP
IMP: Inferred from mutant phenotype
16806156 MGI
acts upstream of or within germ cell migration IMP
IMP: Inferred from mutant phenotype
15993878 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
17078885 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
11285230 MGI
acts upstream of or within kidney development IGI
IGI: Inferred from genetic interaction
16845371 MGI
acts upstream of or within lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
11641223 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
23342175 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16806156 MGI
involved in negative regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19494318 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
21832243 MGI
acts upstream of or within neuron fate commitment IMP
IMP: Inferred from mutant phenotype
15744664 MGI
acts upstream of or within parathyroid gland development IMP
IMP: Inferred from mutant phenotype
17078885 MGI
acts upstream of or within pharyngeal system development IMP
IMP: Inferred from mutant phenotype
17078885 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
24835278 MGI
involved in positive regulation of epithelial to mesenchymal transition IGI
IGI: Inferred from genetic interaction
18718461 MGI
involved in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: Inferred from mutant phenotype
18718461 MGI
acts upstream of or within positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
16806156 MGI
involved in positive regulation of stress fiber assembly IGI
IGI: Inferred from genetic interaction
18718461 MGI
involved in positive regulation of tight junction disassembly IGI
IGI: Inferred from genetic interaction
18718461 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
16806156 MGI
NOT involved in proepicardium development IMP
IMP: Inferred from mutant phenotype
18718461 MGI
involved in regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18718461 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16806156 MGI
acts upstream of or within regulation of protein binding IMP
IMP: Inferred from mutant phenotype
16601693 MGI
involved in response to cholesterol IDA
IDA: Inferred from direct assay
17878231 MGI
acts upstream of or within roof of mouth development IGI
IGI: Inferred from genetic interaction
16845371 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
16806156 MGI
acts upstream of or within skeletal system development IGI
IGI: Inferred from genetic interaction
16845371 MGI
acts upstream of or within skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
16845371 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
17078885 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
14580334 MGI
involved in transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18718461 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11285230 MGI
involved in ventricular compact myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
18718461 MGI
involved in ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
18718461 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
18718461 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
21266196 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfbr1 Protein Structure

Activin_recp

Activin_recp: pfam01064 (29 - 105)

TGF_beta_GS

TGF_beta_GS: pfam08515 (175 - 202)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (208 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

TGF-beta receptor type-1

  • TGF-beta receptor type I

  • transforming growth factor-beta receptor type I

Recombinant Tgfbr1 Proteins

Cat. No. Product Name Accession Purity
HY-P72454 TGFBR1/ALK-5 Protein, Mouse (HEK293, Fc) Q64729 (L30-E125) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136244 PF-06952229 Inhibitor 99.92% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164793 TGFBR1-IN-2 / Unkown
HY-122856 AZ12601011 Inhibitor 99.78% Unkown
HY-N7694 Isotoosendanin 99.51% Unkown
HY-123900 AZ12799734 Inhibitor 98.67% Unkown
HY-RS14444 TGFBR1 Human Pre-designed siRNA Set A / Unkown
HY-RS14445 Tgfbr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14446 TGFBR1 Rat Pre-designed siRNA Set A / Unkown
HY-174531 Human TGFBR1 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfbr1 NCBI NCBI:7046