Tgif1 - TGFB-induced factor homeobox 1 Gene

Also Known as Tgif

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21815

Summary

Enables chromatin binding activity. Acts upstream of or within several processes, including negative regulation of retinoic acid receptor signaling pathway; nodal signaling pathway; and positive regulation of fibroblast proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo ectoderm; and genitourinary system. Used to study otitis media. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Tgif1 Products (5)

mRNA Protein Name
NM_001164074.1 NP_001157546.1 homeobox protein TGIF1 isoform c
NM_001164075.1 NP_001157547.1 homeobox protein TGIF1 isoform a
NM_001164076.1 NP_001157548.1 homeobox protein TGIF1 isoform c
NM_001164077.1 NP_001157549.1 homeobox protein TGIF1 isoform c
NM_009372.3 NP_033398.2 homeobox protein TGIF1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16428452 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16428452 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of amacrine cell differentiation IDA
IDA: Inferred from direct assay
18973577 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17082251 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
16705179 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
17082251 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
16705179 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17082251 MGI
acts upstream of or within negative regulation of retinoic acid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16428452 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16428452 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
17082251 MGI
acts upstream of neuron differentiation IDA
IDA: Inferred from direct assay
18973577 MGI
acts upstream of or within nodal signaling pathway IGI
IGI: Inferred from genetic interaction
20040491 MGI
acts upstream of or within positive regulation of amacrine cell differentiation IDA
IDA: Inferred from direct assay
18973577 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
16705179 MGI
acts upstream of or within regulation of gastrulation IGI
IGI: Inferred from genetic interaction
20040491 MGI
acts upstream of or within retina development in camera-type eye IDA
IDA: Inferred from direct assay
18973577 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
21503901 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein TGIF1

  • 5'-TG-3'-interacting factor 1

  • TALE family homeobox

  • TG interacting factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14455 TGIF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20113 Tgif1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26617 Tgif1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgif1 NCBI NCBI:7050