Kdm1b - lysine (K)-specific demethylase 1B Gene

Also Known as Aof1; 4632428N09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 218214

Summary

Enables flavin adenine dinucleotide binding activity; histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity; and zinc ion binding activity. Involved in regulation of DNA methylation. Acts upstream of or within DNA methylation involved in gamete generation; histone H3-K4 demethylation; and regulation of gene expression by genetic imprinting. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human KDM1B (lysine demethylase 1B). [provided by Alliance of Genome Resources, Apr 2022]

Kdm1b Products (3)

mRNA Protein Name
NM_001402908.1 NP_001389837.1 lysine-specific histone demethylase 1B isoform 2
NM_001402909.1 NP_001389838.1 lysine-specific histone demethylase 1B isoform 3
NM_172262.4 NP_758466.1 lysine-specific histone demethylase 1B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables FAD-dependent H3K4me/H3K4me3 demethylase activity IDA
IDA: Inferred from direct assay
19407342 MGI
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
19407342 MGI
enables histone H3K4 demethylase activity IDA
IDA: Inferred from direct assay
19407342 MGI
NOT enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity IDA
IDA: Inferred from direct assay
19407342 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22878500 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
19407342 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epigenetic programing of female pronucleus IMP
IMP: Inferred from mutant phenotype
19727073 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
19727073 MGI
involved in genomic imprinting IMP
IMP: Inferred from mutant phenotype
19727073 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19727073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific histone demethylase 1B

  • amine oxidase, flavin containing 1

  • flavin-containing amine oxidase domain-containing protein 1

  • lysine-specific histone demethylase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07208 KDM1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21615 Kdm1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28133 Kdm1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm1b NCBI NCBI:221656