Tnfaip3 - tumor necrosis factor, alpha-induced protein 3 Gene

Also Known as A20; Tnfip3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21929

Summary

Enables kinase binding activity and protein C-terminus binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within establishment of protein localization to vacuole; positive regulation of cellular protein catabolic process; and protein K63-linked deubiquitination. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; heart; and retina nuclear layer. Human ortholog(s) of this gene implicated in familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Tnfaip3 Products (2)

mRNA Protein Name
NM_001166402.1 NP_001159874.1 tumor necrosis factor alpha-induced protein 3 isoform 2
NM_009397.3 NP_033423.3 tumor necrosis factor alpha-induced protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase binding IDA
IDA: Inferred from direct assay
18342009 MGI
enables protein binding IDA
IDA: Inferred from direct assay
22733818 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10385526 MGI
Biological Process GO Annotation Evidence References Source
involved in B-1 B cell homeostasis IMP
IMP: Inferred from mutant phenotype
21088135 MGI
involved in cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
23609450 MGI
acts upstream of or within establishment of protein localization to vacuole IDA
IDA: Inferred from direct assay
18952128 MGI
involved in negative regulation of B cell activation IDA
IDA: Inferred from direct assay
21088135 MGI
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
18342009 MGI
involved in negative regulation of chronic inflammatory response IMP
IMP: Inferred from mutant phenotype
18006655 MGI
involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15962316 MGI
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
11009421 MGI
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
23609450 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
21088135 MGI
involved in negative regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
23609450 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
18006655 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
18006655 MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
IMP: Inferred from mutant phenotype
18342009 MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
IDA: Inferred from direct assay
18342009 MGI
involved in negative regulation of toll-like receptor 5 signaling pathway IDA
IDA: Inferred from direct assay
19912257 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
21088135 MGI
involved in positive regulation of hepatocyte proliferation IDA
IDA: Inferred from direct assay
15962316 MGI
acts upstream of or within positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
18952128 MGI
acts upstream of or within protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
24012418 MGI
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
18342009 MGI
involved in regulation of germinal center formation IMP
IMP: Inferred from mutant phenotype
21088135 MGI
involved in response to molecule of bacterial origin IDA
IDA: Inferred from direct assay
19912257 MGI
involved in response to muramyl dipeptide IMP
IMP: Inferred from mutant phenotype
18342009 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10385526 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor alpha-induced protein 3

  • TNF alpha-induced protein 3

  • putative DNA-binding protein A20

  • tumor necrosis factor induced protein 3

  • zinc finger protein A20

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-170863 ZSH-2208 Agonist 99.90% Unkown
HY-RS14789 TNFAIP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17044 Tnfaip3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23488 Tnfaip3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfaip3 NCBI NCBI:7128