FCER1A - Fc epsilon receptor Ia Gene

Homo sapiens

Also known as FCE1A; FcERI; FCERIA

Gene ID: 2205 | Gene type: protein coding

About FCER1A

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,283,575-159,308,202 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 17 paralogues. Broad expression in skin (RPKM 12.7), esophagus (RPKM 10.4) and 20 other tissues.

Summary

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

FCER1A Products(4)

mRNA	Protein	Name
NM_001387280.1	NP_001374209.1	high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor
NM_001387281.1	NP_001374210.1	high affinity immunoglobulin epsilon receptor subunit alpha isoform 3 precursor
NM_001387282.1	NP_001374211.1	high affinity immunoglobulin epsilon receptor subunit alpha isoform 2 precursor
NM_002001.4	NP_001992.1	high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor

FCER1A Protein Structure

Ig_2

0
100
200
257 a.a.

Protein Preferred Names

Protein Names

high affinity immunoglobulin epsilon receptor subunit alpha

Fc IgE receptor, alpha polypeptide

Recombinant FCER1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72191	Fc epsilon RIA/FCER1A Protein, Human (His-SUMO)	P12319 (V26-Q205)	≥95%

Related Diseases

Diseases

Alias

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Chronic Urticaria

Urticaria Chronic	Chronic Spontaneous Urticaria
Chronic Ordinary Urticaria

Physical Urticaria

Symptomatic Dermographism

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Dermatographia

Dermatographic Urticaria	Dermographism
Symptomatic Dermographism	Urticaria Factitia
Factitious Urticaria	Dermatographism

Allergic Rhinitis

Hay Fever	Allergic Rhinitis, Susceptibility To
ALRH	Atopic Rhinitis
Seasonal Allergic Rhinitis	Non-Seasonal Allergic Rhinitis
Perenial Allergic Rhinitis	Pollenosis
Rhinitis Allergic Seasonal	Rhinitis, Allergic, Perennial
Allergic Rhinitis, Cause Unspecified	Pollinosis
Pollen Allergy	Allergy Nos Due To Pollen
Summer Catarrh	Other Seasonal Allergic Rhinitis

Amoxicillin Allergy

Chronic Inducible Urticaria

Cholinergic Urticaria

Allergic Urticaria

Trombiculiasis

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04822	FCER1A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FCER1A	VGNC	VGNC:28930
Felis catus	FCER1A	VGNC	VGNC:62208
Canis familiaris	FCER1A	VGNC	VGNC:40801
Macaca mulatta	FCER1A	VGNC	VGNC:72628
Mus musculus	FCER1A	MGD	MGI:95494
Rattus norvegicus	FCER1A	RGD	RGD:2597
Others	FCER1A	NCBI

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