FCER1A - Fc epsilon receptor Ia Gene

Also Known as FCE1A; FcERI; FCERIA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2205

About FCER1A

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,283,575-159,308,202 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 17 paralogues. Broad expression in skin (RPKM 12.7), esophagus (RPKM 10.4) and 20 other tissues.

Summary

The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]

FCER1A Products (4)

mRNA Protein Name
NM_001387280.1 NP_001374209.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor
NM_001387281.1 NP_001374210.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 3 precursor
NM_001387282.1 NP_001374211.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 2 precursor
NM_002001.4 NP_001992.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables IgE binding IDA
IDA: Inferred from direct assay
10917520 GOA
enables high-affinity IgE receptor activity IDA
IDA: Inferred from direct assay
8114916 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10917520 GOA
Biological Process GO Annotation Evidence References Source
involved in eosinophil degranulation IDA
IDA: Inferred from direct assay
8114916 GOA
involved in mast cell degranulation IMP
IMP: Inferred from mutant phenotype
8551243 GOA
involved in type 2 immune response IDA
IDA: Inferred from direct assay
8114916 GOA
involved in type I hypersensitivity IMP
IMP: Inferred from mutant phenotype
8551243 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
1535625 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8114916 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCER1A Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (30 - 104)

Ig_2

Ig_2: Immunoglobulin domain (114 - 194)

  • 0
  • 100
  • 200
  • 257 a.a.
Protein Preferred Names Protein Names

high affinity immunoglobulin epsilon receptor subunit alpha

  • Fc IgE receptor, alpha polypeptide

FCER1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FCER1A P12319 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
Intra
FCER1A P12319 MESD Homo sapiens Q14696
Validated Y2H
32296183
Intra
FCER1A P12319 MESD Homo sapiens Q14696
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCER1A Proteins

Cat. No. Product Name Accession Purity
HY-P72191 Fc epsilon RIA/FCER1A Protein, Human (His-SUMO) P12319 (V26-Q205) ≥ 95%, as determined by reducing SDS-PAGE.

FCER1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P84075 FCER1A Antibody (YA3772) WB, FC, ELISA Human
HY-P84075A FCER1A Antibody (YA3772)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Chronic Spontaneous Urticaria

  • Chronic Idiopathic Urticaria
Chronic Urticaria

  • Urticaria Chronic

  • Chronic Spontaneous Urticaria

  • Chronic Ordinary Urticaria
Physical Urticaria

  • Symptomatic Dermographism
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Dermatographia

  • Dermatographic Urticaria

  • Dermographism

  • Symptomatic Dermographism

  • Urticaria Factitia

  • Factitious Urticaria

  • Dermatographism
Allergic Rhinitis

  • Hay Fever

  • Allergic Rhinitis, Susceptibility To

  • ALRH

  • Atopic Rhinitis

  • Seasonal Allergic Rhinitis

  • Non-Seasonal Allergic Rhinitis

  • Perenial Allergic Rhinitis

  • Pollenosis

  • Rhinitis Allergic Seasonal

  • Rhinitis, Allergic, Perennial

  • Allergic Rhinitis, Cause Unspecified

  • Pollinosis

  • Pollen Allergy

  • Allergy Nos Due To Pollen

  • Summer Catarrh

  • Other Seasonal Allergic Rhinitis
Amoxicillin Allergy
Chronic Inducible Urticaria
Cholinergic Urticaria
Allergic Urticaria
Trombiculiasis
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04822 FCER1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18422 Fcer1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24903 Fcer1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FCER1A VGNC VGNC:28930
Felis catus FCER1A VGNC VGNC:62208
Canis familiaris FCER1A VGNC VGNC:40801
Macaca mulatta FCER1A VGNC VGNC:72628
Mus musculus FCER1A MGD MGI:95494
Rattus norvegicus FCER1A RGD RGD:2597
Others FCER1A NCBI