MICU2 - mitochondrial calcium uptake 2 Gene

Also Known as EFHA1; 1110008L20Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221154

About MICU2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:21,492,691-21,604,170 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 25.3), adrenal (RPKM 19.4) and 25 other tissues.

Summary

Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022]

MICU2 Products (1)

mRNA Protein Name
NM_152726.3 NP_689939.1 calcium uptake protein 2, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
31397067 GOA
enables calcium ion sensor activity IDA
IDA: Inferred from direct assay
28615291 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24560927 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
24560927 GOA
Biological Process GO Annotation Evidence References Source
involved in calcium import into the mitochondrion IDA
IDA: Inferred from direct assay
28615291 GOA
involved in calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
26903221 GOA
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
32494073 GOA
involved in mitochondrial calcium ion homeostasis IDA
IDA: Inferred from direct assay
32494073 GOA
involved in mitochondrial calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
26903221 GOA
involved in mitochondrial calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
24560927 GOA
involved in negative regulation of mitochondrial calcium ion concentration IDA
IDA: Inferred from direct assay
24560927 GOA
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28615291 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
27099988 GOA
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
24231807 GOA
part of uniplex complex IDA
IDA: Inferred from direct assay
24231807 GOA
part of uniplex complex IPI
IPI: Inferred from physical interaction
32494073 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICU2 Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (348 - 393)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 434 a.a.
Protein Preferred Names Protein Names

calcium uptake protein 2, mitochondrial

  • EF hand domain family A1

MICU2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MICU2 Q8IYU8 MICU1 Homo sapiens Q9BPX6
Anti Bait CoIP
26387864
Intra
MICU2 Q8IYU8 MICU1 Homo sapiens Q9BPX6
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

MICU2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86962 MICU2 Antibody (YA6655) WB, IHC-P, IF-Tissue, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Myopathy With Extrapyramidal Signs

  • Proximal Myopathy With Extrapyramidal Signs

  • MPXPS

  • Myopathy, With Extrapyramidal Signs
Sagittal Sinus Thrombosis

  • Thrombosis Of Superior Longitudinal Sinus

  • Thrombosis Of Superior Sagittal Sinus

  • Thrombosis Superior Sagittal Sinus
Ovarian Endometrial Cancer

  • Endometrioid Neoplasm Of Ovary

  • Malignant Ovarian Endometrioid Tumor

  • Ovarian Endometrioid Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08432 MICU2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21647 Micu2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28165 Micu2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MICU2 MGD MGI:1915764
Macaca mulatta MICU2 VGNC VGNC:74629
Rattus norvegicus MICU2 RGD RGD:619739
Felis catus MICU2 VGNC VGNC:63495
Canis familiaris MICU2 VGNC VGNC:43221
Bos taurus MICU2 VGNC VGNC:31462
Others MICU2 NCBI