2. Gene
  3. MICU2 - mitochondrial calcium uptake 2 Gene

MICU2 - mitochondrial calcium uptake 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EFHA1; 1110008L20Rik

Gene ID: 221154 | Gene type: protein coding

About MICU2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:21,492,691-21,604,170 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 25.3), adrenal (RPKM 19.4) and 25 other tissues.

Summary

Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022]

MICU2 Products(1)

mRNA Protein Name
NM_152726.3 NP_689939.1 calcium uptake protein 2, mitochondrial

MICU2 Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (348 - 393)

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  • 434 a.a.
Protein Preferred Names Protein Names

calcium uptake protein 2, mitochondrial

EF hand domain family A1

Related Diseases

Diseases Alias
Myopathy With Extrapyramidal Signs

Proximal Myopathy With Extrapyramidal Signs

MPXPS

Myopathy, With Extrapyramidal Signs
Sagittal Sinus Thrombosis

Thrombosis Of Superior Longitudinal Sinus

Thrombosis Of Superior Sagittal Sinus

Thrombosis Superior Sagittal Sinus
Ovarian Endometrial Cancer

Endometrioid Neoplasm Of Ovary

Malignant Ovarian Endometrioid Tumor

Ovarian Endometrioid Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08432 MICU2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MICU2 MGD MGI:1915764
Macaca mulatta MICU2 VGNC VGNC:74629
Rattus norvegicus MICU2 RGD RGD:619739
Felis catus MICU2 VGNC VGNC:63495
Canis familiaris MICU2 VGNC VGNC:43221
Bos taurus MICU2 VGNC VGNC:31462