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Tyrobp - TYRO protein tyrosine kinase binding protein Gene

Also Known as Ly83; DAP12; KARAP

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22177

Summary

Enables signaling receptor binding activity. Involved in several processes, including myeloid cell activation involved in immune response; regulation of cytokine production; and regulation of lymphocyte activation. Acts upstream of or within osteoclast differentiation and regulation of osteoclast development. Located in cell surface. Is expressed in blood vessel; brain; central nervous system; corpus callosum; and embryo. Used to study Nasu-Hakola disease. Human ortholog(s) of this gene implicated in Nasu-Hakola disease. Orthologous to human TYROBP (transmembrane immune signaling adaptor TYROBP). [provided by Alliance of Genome Resources, Apr 2022]

Tyrobp Products (1)

mRNA	Protein	Name
NM_011662.3	NP_035792.1	TYRO protein tyrosine kinase-binding protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647200	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16715077	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA IDA: Inferred from direct assay	16715077	MGI
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18691974	MGI
involved in apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	15728241	MGI
involved in forebrain development	IDA IDA: Inferred from direct assay	18685038	MGI
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17086186	MGI
involved in macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	17086186	MGI
involved in microglial cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	25690660	MGI
involved in negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	21727189	MGI
involved in negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	25690660	MGI
involved in negative regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	15601948	MGI
involved in negative regulation of transforming growth factor beta1 production	IMP IMP: Inferred from mutant phenotype	25690660	MGI
involved in neutrophil activation involved in immune response	IMP IMP: Inferred from mutant phenotype	17086186	MGI
acts upstream of or within osteoclast differentiation	IDA IDA: Inferred from direct assay	21841309	MGI
acts upstream of or within osteoclast differentiation	IGI IGI: Inferred from genetic interaction	21841309	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21841309	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25690660	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	25690660	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	25690660	MGI
involved in positive regulation of macrophage fusion	IMP IMP: Inferred from mutant phenotype	18957693	MGI
involved in positive regulation of microglial cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	18685038	MGI
involved in positive regulation of natural killer cell activation	IDA IDA: Inferred from direct assay	9647200	MGI
involved in positive regulation of osteoclast development	IMP IMP: Inferred from mutant phenotype	14969392	MGI
involved in positive regulation of receptor localization to synapse	IMP IMP: Inferred from mutant phenotype	15601948	MGI
involved in positive regulation of superoxide anion generation	IDA IDA: Inferred from direct assay	18685038	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	25690660	MGI
acts upstream of or within regulation of osteoclast development	IGI IGI: Inferred from genetic interaction	22451653	MGI
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	25690660	MGI
involved in semaphorin-plexin signaling pathway	IDA IDA: Inferred from direct assay	16715077	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	9647200	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
TYRO protein tyrosine kinase-binding protein	DNAX-activation protein 12 KAR-associated protein killer cell activating receptor associated protein killer-activating receptor-associated protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15309	TYROBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21215	Tyrobp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27731	Tyrobp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tyrobp	NCBI	NCBI:7305