Ube2i - ubiquitin-conjugating enzyme E2I Gene

Also Known as UBC9; Ubce9; Ubce2i; 5830467E05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22196

Summary

Enables HLH domain binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in nuclear body. Is expressed in several structures, including early embryo; forebrain; forelimb bud; limb; and oocyte. Orthologous to human UBE2I (Ubiquitin Conjugating Enzyme E2 I). [provided by Alliance of Genome Resources, Apr 2022]

Ube2i Products (4)

mRNA Protein Name
NM_001177609.1 NP_001171080.1 SUMO-conjugating enzyme UBC9
NM_001177610.1 NP_001171081.1 SUMO-conjugating enzyme UBC9
NM_001357694.1 NP_001344623.1 SUMO-conjugating enzyme UBC9
NM_011665.4 NP_035795.1 SUMO-conjugating enzyme UBC9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables HLH domain binding IPI
IPI: Inferred from physical interaction
9409784 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9223278 MGI
Biological Process GO Annotation Evidence References Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
25448527 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
25448527 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16127449 MGI
involved in nuclear export EXP
EXP: Inferred from Experiment
27160050 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
9223278 MGI
Cellular Component GO Annotation Evidence References Source
part of SUMO ligase complex IDA
IDA: Inferred from direct assay
22207709 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
25448527 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
25448527 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31749687 MGI
located in nuclear body IDA
IDA: Inferred from direct assay
18681895 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
31749687 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
31749687 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SUMO-conjugating enzyme UBC9

  • RING-type E3 SUMO transferase UBC9

  • SUMO-protein ligase

  • ubiquitin carrier protein 9

  • ubiquitin carrier protein I

  • ubiquitin-protein ligase I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15349 UBE2I Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18848 Ube2i Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25340 Ube2i Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ube2i NCBI NCBI:7329