UBE2I - ubiquitin conjugating enzyme E2 I Gene

Homo sapiens

Also known as P18; UBC9; C358B7.1

Gene ID: 7329 | Gene type: protein coding

About UBE2I

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,309,152-1,327,017 (from NCBI)

This gene has 24 transcripts (splice variants), 243 orthologues and 24 paralogues. Ubiquitous expression in ovary (RPKM 23.2), endometrium (RPKM 17.8) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UBE2I Products(4)

mRNA	Protein	Name
NM_003345.5	NP_003336.1	SUMO-conjugating enzyme UBC9
NM_194259.3	NP_919235.1	SUMO-conjugating enzyme UBC9
NM_194260.3	NP_919236.1	SUMO-conjugating enzyme UBC9
NM_194261.3	NP_919237.1	SUMO-conjugating enzyme UBC9

UBE2I Protein Structure

UQ_con

0
100
158 a.a.

Protein Preferred Names

Protein Names

SUMO-conjugating enzyme UBC9

RING-type E3 SUMO transferase UBC9

Recombinant UBE2I Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71403	UBE2I Protein, Human (GST)	P63279 (M1-S158)	≥95%

Related Diseases

Diseases

Alias

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15349	UBE2I Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UBE2I	VGNC	VGNC:99624
Canis familiaris	UBE2I	VGNC	VGNC:54084
Bos taurus	UBE2I	VGNC	VGNC:36584
Mus musculus	UBE2I	MGD	MGI:107365
Felis catus	UBE2I	VGNC	VGNC:80700
Rattus norvegicus	UBE2I	RGD	RGD:3926
Others	UBE2I	NCBI

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