UBE2I - ubiquitin conjugating enzyme E2 I Gene

Also Known as P18; UBC9; C358B7.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7329

About UBE2I

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,309,152-1,327,017 (from NCBI)

This gene has 24 transcripts (splice variants), 243 orthologues and 24 paralogues. Ubiquitous expression in ovary (RPKM 23.2), endometrium (RPKM 17.8) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UBE2I Products (4)

mRNA Protein Name
NM_003345.5 NP_003336.1 SUMO-conjugating enzyme UBC9
NM_194259.3 NP_919235.1 SUMO-conjugating enzyme UBC9
NM_194260.3 NP_919236.1 SUMO-conjugating enzyme UBC9
NM_194261.3 NP_919237.1 SUMO-conjugating enzyme UBC9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RING-like zinc finger domain binding IPI
IPI: Inferred from physical interaction
19407830 GOA
enables SUMO conjugating enzyme activity IDA
IDA: Inferred from direct assay
19955185 GOA
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
11877416 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
17087506 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9885291 GOA
enables small protein activating enzyme binding IPI
IPI: Inferred from physical interaction
15660128 GOA
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
20215116 GOA
enables transcription factor binding IPI
IPI: Inferred from physical interaction
19744555 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16631117 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19955185 GOA
involved in nuclear export EXP
EXP: Inferred from Experiment
27160050 GOA
involved in positive regulation of SUMO transferase activity IDA
IDA: Inferred from direct assay
19955185 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20023705 GOA
involved in protein sumoylation IDA
IDA: Inferred from direct assay
15660128 GOA
involved in protein sumoylation IMP
IMP: Inferred from mutant phenotype
26620705 GOA
Cellular Component GO Annotation Evidence References Source
located in PML body IDA
IDA: Inferred from direct assay
9885291 GOA
part of SUMO ligase complex IPI
IPI: Inferred from physical interaction
22194619 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9223278 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9223278 GOA
part of transferase complex IDA
IDA: Inferred from direct assay
19955185 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2I Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 151)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

SUMO-conjugating enzyme UBC9

  • RING-type E3 SUMO transferase UBC9

UBE2I Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2I P63279 SUMO1P1 Homo sapiens G2XKQ0
Y2H Prey Pooling
25416956
Intra
UBE2I P63279 SUMO1P1 Homo sapiens G2XKQ0
Validated Y2H
25416956
Intra
UBE2I P63279 SUMO1P1 Homo sapiens G2XKQ0
Y2H Array
25416956
Intra
UBE2I P63279 SOX10 Homo sapiens P56693
Anti Tag CoIP
16494873
Intra
UBE2I P63279 SETX Homo sapiens Q7Z333
Y2H
24244371
Intra
UBE2I P63279 RWDD3 Homo sapiens Q9Y3V2
Pull Down
17956732
Intra
UBE2I P63279 RWDD3 Homo sapiens Q9Y3V2
Confocal
17956732
Intra
UBE2I P63279 RNF111 Homo sapiens Q6ZNA4
Y2H Array
19549727
Intra
UBE2I P63279 RNF111 Homo sapiens Q6ZNA4
Y2H Prey Pooling
25416956
Intra
UBE2I P63279 GMCL1 Homo sapiens Q96IK5
BFG-2H
27107012
Intra
UBE2I P63279 EDARADD Homo sapiens Q8WWZ3
Y2H Prey Pooling
25416956
Intra
UBE2I P63279 HDAC4 Homo sapiens P56524
Y2H
16166628
Intra
UBE2I P63279 HDAC4 Homo sapiens P56524
Anti Tag CoIP
16166628
Intra
UBE2I P63279 SMAD4 Homo sapiens Q13485
Y2H
21988832
Intra
UBE2I P63279 SMAD4 Homo sapiens Q13485
Y2H
15231748
Intra
UBE2I P63279 SMAD4 Homo sapiens Q13485
Y2H Array
31515488
Intra
UBE2I P63279 SMAD4 Homo sapiens Q13485
Y2H Array
29892012
Intra
UBE2I P63279 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
21988832
Intra
UBE2I P63279 TFAP2A Homo sapiens P05549
Pull Down
24835590
Intra
UBE2I P63279 TFAP2A Homo sapiens P05549
Y2H
12072434
Intra
UBE2I P63279 PIAS2 Homo sapiens O75928
Validated Y2H
25416956
Intra
UBE2I P63279 PIAS2 Homo sapiens O75928
Y2H Pooling
16189514
Intra
UBE2I P63279 PIAS2 Homo sapiens O75928
Y2H Array
25416956
Intra
UBE2I P63279 TP53 Homo sapiens P04637
Anti Tag CoIP
15327968
Intra
UBE2I P63279 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
25416956
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
X-Ray Diffraction
16732283
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
GMS
16732283
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
Anti Tag CoIP
33961781
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
Pull Down
17036045
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
Anti Tag CoIP
26496610
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
Y2H
19549727
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
Anti Tag CoIP
28514442
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
Anti Bait CoIP
17353931
Intra
UBE2I P63279 RANGAP1 Homo sapiens P46060
Confocal
21988832
Intra
UBE2I P63279 SUMO2 Homo sapiens P61956
Anti Tag CoIP
33961781
Intra
UBE2I P63279 SUMO2 Homo sapiens P61956
GMS
17491593
Intra
UBE2I P63279 SUMO2 Homo sapiens P61956
Anti Tag CoIP
28514442
Intra
UBE2I P63279 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Cross
UBE2I P63279 E1 Bovine papillomavirus P03116
Y2H
10871618
Intra
UBE2I P63279 UBA1 Homo sapiens P22314
Pull Down
17956732
Intra
UBE2I P63279 BHLHE40 Homo sapiens O14503
Anti Tag CoIP
11278694
Intra
UBE2I P63279 BHLHE40 Homo sapiens O14503
Yeast Display
11278694
Intra
UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Anti Bait CoIP
17353931
Intra
UBE2I P63279 UBA2 Homo sapiens Q9UBT2
NMR
17643372
Intra
UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Anti Tag CoIP
26496610
Intra
UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Anti Tag CoIP
33961781
Intra
UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Anti Tag CoIP
28514442
Intra
UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Sumoylase Assay
17643372
Intra
UBE2I P63279 ZCCHC7 Homo sapiens Q8N3Z6
Validated Y2H
25416956
Intra
UBE2I P63279 ZCCHC7 Homo sapiens Q8N3Z6
Y2H Array
25416956
Intra
UBE2I P63279 ZCCHC7 Homo sapiens Q8N3Z6
Y2H Prey Pooling
25416956
Intra
UBE2I P63279 ELK1 Homo sapiens P19419
Pull Down
17036045
Intra
UBE2I P63279 ELK1 Homo sapiens P19419
Anti Tag CoIP
23395904
Intra
UBE2I P63279 ELK1 Homo sapiens P19419
Enzymatic Study
17036045
Intra
UBE2I P63279 ELK1 Homo sapiens P19419
Anti Bait CoIP
17036045
Intra
UBE2I P63279 ELK1 Homo sapiens P19419
Pull Down
23395904
Intra
UBE2I P63279 ZNF451 Homo sapiens Q9Y4E5
Y2H Pooling
20936779
Intra
UBE2I P63279 ZNF451 Homo sapiens Q9Y4E5
Y2H Pooling
16189514
Intra
UBE2I P63279 ZNF451 Homo sapiens Q9Y4E5
Y2H
21516116
Intra
UBE2I P63279 IPO13 Homo sapiens O94829
Pull Down
21139563
Intra
UBE2I P63279 CHMP4B Homo sapiens Q9H444
Y2H Pooling
16189514
Intra
UBE2I P63279 CHMP4B Homo sapiens Q9H444
Y2H
16730941
Cross
UBE2I P63279 N Human SARS coronavirus P59595
Confocal
17037517
Cross
UBE2I P63279 N Human SARS coronavirus P59595
Pull Down
16998888
Intra
UBE2I P63279 DAXX Homo sapiens Q9UER7
Y2H
11112409
Intra
UBE2I P63279 DAXX Homo sapiens Q9UER7
Anti Tag CoIP
23395904
Intra
UBE2I P63279 DNMT3B Homo sapiens Q9UBC3
Y2H
11735126
Intra
UBE2I P63279 DNMT3B Homo sapiens Q9UBC3
Pull Down
11735126
Intra
UBE2I P63279 SUMO1 Homo sapiens P63165
GMS
17491593
Intra
UBE2I P63279 SUMO1 Homo sapiens P63165
Comigration in SDS
18264111
Intra
UBE2I P63279 SUMO1 Homo sapiens P63165
Anti Bait CoIP
17353931
Intra
UBE2I P63279 SUMO1 Homo sapiens P63165
Comigration in SDS
16732283
Intra
UBE2I P63279 SUMO1 Homo sapiens P63165
Pull Down
17956732
Intra
UBE2I P63279 SUMO1 Homo sapiens P63165
ITC
17491593
Intra
UBE2I P63279 SUMO1 Homo sapiens P63165
Anti Tag CoIP
26496610
Intra
UBE2I P63279 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
UBE2I P63279 RANBP2 Homo sapiens P49792
Anti Tag CoIP
26496610
Intra
UBE2I P63279 RANBP2 Homo sapiens P49792
Anti Tag CoIP
33961781
Intra
UBE2I P63279 RANBP2 Homo sapiens P49792
Anti Bait CoIP
17353931
Intra
UBE2I P63279 RANBP2 Homo sapiens P49792
Anti Tag CoIP
28514442
Cross
UBE2I P63279 LMP1 Epstein-Barr virus P03230
Anti Tag CoIP
21795333
Cross
UBE2I P63279 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Y2H
21911577
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2I Proteins

Cat. No. Product Name Accession Purity
HY-P71403 UBE2I Protein, Human (GST) P63279 (M1-S158) ≥ 95%, as determined by reducing SDS-PAGE.

UBE2I Antibodies

Cat. No. Product Name Application Reactivity
HY-P83556 SUMO Conjugating Enzyme UBC9 Antibody (YA3301) WB, IHC-P, IHC-F, ICC/IF, IP, FC Human, Mouse, Rat
HY-P83556A SUMO Conjugating Enzyme UBC9 Antibody (YA3301)(PBS only) WB, IHC-P, IHC-F, ICC/IF, IP, FC Human, Mouse, Rat
HY-P85404 SUMO Conjugating Enzyme UBC9 Antibody (YA5096) WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC Human, Mouse

Related Diseases

Diseases Alias
Microphthalmia

  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15349 UBE2I Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18848 Ube2i Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25340 Ube2i Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBE2I VGNC VGNC:99624
Canis familiaris UBE2I VGNC VGNC:54084
Bos taurus UBE2I VGNC VGNC:36584
Mus musculus UBE2I MGD MGI:107365
Felis catus UBE2I VGNC VGNC:80700
Rattus norvegicus UBE2I RGD RGD:3926
Others UBE2I NCBI